ArticleJournal of biomedical optics2013
Adaptive wide-field optical tomography.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Medium-adaptive compressive diffuse optical tomography.Biomedical optics express · 2024Article
- Article
- Macroscopic Fluorescence Lifetime Imaging for Monitoring of Drug-Target Engagement.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Hyperspectral wide-field time domain single-pixel diffuse optical tomography platform.Biomedical optics express · 2018Article
- Direct approach to compute Jacobians for diffuse optical tomography using perturbation Monte Carlo-based photon "replay".Biomedical optics express · 2018Article
- Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018Review
- Tomographic phosphorescence lifetime multiplexing.Optics letters · 2018Article
- Article
- Generalized mesh-based Monte Carlo for wide-field illumination and detection via mesh retessellation.Biomedical optics express · 2016Article
- Assessment of Gate Width Size on Lifetime-Based Förster Resonance Energy Transfer Parameter Estimation.Photonics · 2015Article
- Hyperspectral time-resolved wide-field fluorescence molecular tomography based on structured light and single-pixel detection.Optics letters · 2015Article
- Reduced temporal sampling effect on accuracy of time-domain fluorescence lifetime Förster resonance energy transfer.Journal of biomedical optics · 2014Article
- Spatial light modulator based active wide-field illumination for ex vivo and in vivo quantitative NIR FRET imaging.Biomedical optics express · 2014Article
- Hadamard multiplexed fluorescence tomography.Biomedical optics express · 2014Article
- Active wide-field illumination for high-throughput fluorescence lifetime imaging.Optics letters · 2013Article
- Multi-modal molecular diffuse optical tomography system for small animal imaging.Measurement science & technology · 2013Article
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Authors and funding
2 authors.
Funding
Abstract
We describe a wide-field optical tomography technique, which allows the measurement-guided optimization of illumination patterns for enhanced reconstruction performances. The iterative optimization of the excitation pattern aims at reducing the dynamic range in photons transmitted through biological tissue. It increases the number of measurements collected with high photon counts resulting in a dataset with improved tomographic information. Herein, this imaging technique is applied to time-resolved fluorescence molecular tomography for preclinical studies. First, the merit of this approach is tested by in silico studies in a synthetic small animal model for typical illumination patterns. Second, the applicability of this approach in tomographic imaging is validated in vitro using a small animal phantom with two fluorescent capillaries occluded by a highly absorbing inclusion. The simulation study demonstrates an improvement of signal transmitted (∼2 orders of magnitude) through the central portion of the small animal model for all patterns considered. A corresponding improvement in the signal at the emission wavelength by 1.6 orders of magnitude demonstrates the applicability of this technique for fluorescence molecular tomography. The successful discrimination and localization (∼1 mm error) of the two objects with higher resolution using the optimized patterns compared with nonoptimized illumination establishes the improvement in reconstruction performance when using this technique.
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