ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Candida albicans primes TLR cytokine responses through a Dectin-1/Raf-1-mediated pathway.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 62 citations in OpenAlex.
- Repositioning Antimicrobial Peptides Against WHO-Priority Fungi.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Candida albicans N-Linked Mannans Potentiate the Induction of Trained Immunity via Dectin-2.The Journal of infectious diseases · 2024Article
- Bacteria- and fungus-derived PAMPs induce innate immune memory via similar functional, metabolic, and transcriptional adaptations.Journal of leukocyte biology · 2024Article
- Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks.Scientific reports · 2024Article
- Endotoxin tolerance and trained immunity: breaking down immunological memory barriers.Frontiers in immunology · 2024Review
- Expression of Toll-like receptor 2, Dectin-1, and Osteopontin in murine model of pulpitis.Clinical oral investigations · 2023Article
- Innate immune responses against the fungal pathogen Candida auris.Nature communications · 2022Article
- "Molding" immunity-modulation of mucosal and systemic immunity by the intestinal mycobiome in health and disease.Mucosal immunology · 2022Review
- The Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers.International journal of molecular sciences · 2022Review
- Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections.Cell reports · 2022Article
- Dectin-1 Signaling Update: New Perspectives for Trained Immunity.Frontiers in immunology · 2022Review
- β-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- The double-sided effects of Mycobacterium Bovis bacillus Calmette-Guérin vaccine.NPJ vaccines · 2021Review
- Trained Immunity Confers Prolonged Protection From Listeriosis.Frontiers in immunology · 2021Article
- Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function.International journal of molecular sciences · 2020Review
- Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections.The Journal of infectious diseases · 2020Article
- mTORC1 Is Not Principally Involved in the Induction of Human Endotoxin Tolerance.Frontiers in immunology · 2020Article
- Controlled Human Malaria Infection Induces Long-Term Functional Changes in Monocytes.Frontiers in molecular biosciences · 2020Article
- Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection.Cell reports · 2018Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
The immune system is essential to maintain homeostasis with resident microbial populations, ensuring that the symbiotic host-microbial relationship is maintained. In parallel, commensal microbes significantly shape mammalian immunity at the host mucosal surface, as well as systemically. Candida albicans is an opportunistic pathogen that lives as a commensal on skin and mucosa of healthy individuals. Little is known about its capacity to modulate responses toward other microorganisms, such as colonizing bacteria (e.g., intestinal microorganisms). The aim of this study was to assess the cytokine production of PBMCs induced by commensal bacteria when these cells were primed by C. albicans. We show that C. albicans and β-1,3-glucan induce priming of human primary mononuclear cells and this leads to enhanced cytokine production upon in vitro stimulation with TLR ligands and bacterial commensals. This priming requires the β-1,3-glucan receptor dectin-1 and the noncanonical Raf-1 pathway. In addition, although purified mannans cannot solely mediate the priming, the presence of mannosyl residues in the cell wall of C. albicans is nevertheless required. In conclusion, C. albicans is able to modify cytokine responses to TLR ligands and colonizing bacteria, which is likely to impact the inflammatory reaction during mucosal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.