ArticleWorld journal of urology2014
Calcium oxalate nephrolithiasis and expression of matrix GLA protein in the kidneys.
Article in World journal of urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Steroid hormones and nephrolithiasis: regulation of urine components metabolism and inflammation.Biology of sex differences · 2026Review
- The role of inflammation and ROS in CaOx kidney stones.European journal of medical research · 2025Review
- Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate-Induced Crystal Deposition and Kidney Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advances in the mechanism of urinary proteins in calcium oxalate kidney stone formation.Urolithiasis · 2025Review
- Identification of Protein-Coding Gene Structure and Protein-Related Genes and Their Splicing Sites in Kidney Stone Disease: A Protein Big Data Analysis.Applied biochemistry and biotechnology · 2023Article
- Vitamins as regulators of calcium-containing kidney stones - new perspectives on the role of the gut microbiome.Nature reviews. Urology · 2023Review
- Renal tubular epithelial cells treated with calcium oxalate up-regulate S100A8 and S100A9 expression in M1-polarized macrophages via interleukin 6.Iranian journal of basic medical sciences · 2023Article
- Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation.Nature reviews. Nephrology · 2021Review
- Crosstalk between Renal and Vascular Calcium Signaling: The Link between Nephrolithiasis and Vascular Calcification.International journal of molecular sciences · 2021Review
- Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones.Journal of nephrology · 2020Article
- miR-155-5p Promotes Oxalate- and Calcium-Induced Kidney Oxidative Stress Injury by Suppressing MGP Expression.Oxidative medicine and cellular longevity · 2020Article
- Vitamin K Dependent Proteins in Kidney Disease.International journal of molecular sciences · 2019Review
- Prevalence, pathophysiological mechanisms and factors affecting urolithiasis.International urology and nephrology · 2018Review
- Histological aspects of the "fixed-particle" model of stone formation: animal studies.Urolithiasis · 2017Review
- Article
- Unified theory on the pathogenesis of Randall's plaques and plugs.Urolithiasis · 2015Article
- From crystalluria to kidney stones, some physicochemical aspects of calcium nephrolithiasis.World journal of nephrology · 2014Review
- Expression of Transthyretin during bovine myogenic satellite cell differentiation.In vitro cellular & developmental biology. Animal · 2014Article
- Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis.Translational andrology and urology · 2014Article
- Regulation of macromolecular modulators of urinary stone formation by reactive oxygen species: transcriptional study in an animal model of hyperoxaluria.American journal of physiology. Renal physiology · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectivesPolymorphism of the gene for matrix GLA protein (MGP), a calcification inhibitor, is associated with nephrolithiasis. However, experimental investigations of MGP role in stone pathogenesis are limited. We determined the effect of renal epithelial exposure to oxalate (Ox), calcium oxalate (CaOx) monohydrate (COM) or hydroxyapatite (HA) crystal on the expression of MGP.
methodsMDCK cells in culture were exposed to 0.3, 0.5 or 1 mM Ox and 33, 66 or 133-150 μg/cm(2) of COM/HA for 3-72 h. MGP expression and production were determined by Western blotting and densitometric analysis. Enzyme-linked immunosorbent assay was performed to determine MGP release into the medium. Hyperoxaluria was induced in male Sprague-Dawley rats by feeding hydroxyl-L-proline. Immunohistochemistry was performed to detect renal MGP expression.
resultsExposure to Ox and crystals led to time- and concentration-dependent increase in expression of MGP in MDCK cells. Cellular response was quicker to crystal exposure than to the Ox, expression being significantly higher after 3-h exposure to COM or HA crystals and more than 6 h of exposure to Ox. MGP expression was increased in kidneys of hyperoxaluric rats particularly in renal peritubular vessels.
conclusionWe demonstrate increased expression of MGP in renal tubular epithelial cells exposed to Ox or CaOx crystals as well as the HA crystals. The most significant finding of this study is the increased staining seen in renal peritubular vessels of the hyperoxaluric rats, indicating involvement of renal endothelial cells in the synthesis of MGP.
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