ReviewInternal and emergency medicine2013
Testosterone and cardiovascular risk.
Review in Internal and emergency medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Sleep restriction and testosterone concentrations in young healthy males: randomized controlled studies of acute and chronic short sleep.Sleep health · 2019Trial
- Effect of Vitamin K Supplementation on Testosterone Production in a Rat Model of Late-Onset Hypogonadism.Foods (Basel, Switzerland) · 2026Article
- Sex-related hormonal variances and clinical outcomes in TAVR patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- A 36-year-old man, body builder presenting with unexpected severe anemia.Internal and emergency medicine · 2023Article
- Stress Induced Cortisol Release Depresses The Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus.Clinical medicine insights. Endocrinology and diabetes · 2023Article
- Vascular Pathways of Testosterone: Clinical Implications.Journal of cardiovascular translational research · 2020Review
- Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study.International journal of endocrinology · 2018Article
- Influence of vitamin D levels on the cardiovascular profile of hypogonadal men.Journal of endocrinological investigation · 2017Article
- Androgen receptor GGC repeat might be more involved than CAG repeat in the regulation of the metabolic profile in men.Internal and emergency medicine · 2016Article
- Will testosterone replacement therapy become a new treatment of chronic heart failure? A review based on 8 clinical trials.Journal of thoracic disease · 2016Review
- Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study.International journal of endocrinology · 2016Article
- Basic Science Evidence for the Link Between Erectile Dysfunction and Cardiometabolic Dysfunction.The journal of sexual medicine · 2015Review
- Testosterone deficiency increases hospital readmission and mortality rates in male patients with heart failure.Arquivos brasileiros de cardiologia · 2015Article
- Update on Testosterone Replacement Therapy in Hypogonadal Men.Current urology reports · 2015Review
- Review of health risks of low testosterone and testosterone administration.World journal of clinical cases · 2015Review
- Natural course of hypogonadism diagnosed during hospitalization in aged male patients.Endocrine · 2015Article
- Cross-sex hormone therapy for gender dysphoria.Journal of endocrinological investigation · 2015Review
- The use of dietary supplements to alleviate androgen deprivation therapy side effects during prostate cancer treatment.Nutrients · 2014Review
- Carotid artery intima-media thickness and erectile dysfunction in patients with metabolic syndrome.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular (CV) disease is one of the most common causes of death in the western populations and, nowadays, its incidence is increasing even in the developing countries; although CV disease affects both sexes, it is more frequent in males in whom it shortens the average life expectancy. In this regard, this difference has been wrongly attributed for many years to the negative effects of testosterone (T); however, nowadays, a large amount of evidence suggests that this hormone may have protective effects on the CV system and that, indeed, the low levels of T could be associated with an increased CV risk and with an augmentation of morbidity and mortality in males. Such an aspect gains great relevance in light of the consideration that T decrease, besides occurring as a consequence of rare pathological conditions, can often take place with natural aging, causing a state of "male menopause", also called late-onset hypogonadism. In this review, we aimed to summarize the present state of the art concerning the association between T deficit and CV disease by analyzing the protective role of T on CV system and the relationship of this hormonal lack with metabolic syndrome, CV morbidity and mortality, and with the CV complications, such as ischemic heart disease, heart failure and stroke, that frequently occur in T deficiency.
Indexed as
Identifiers
23475207What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.