ArticleNature medicine2013
Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis.
Article in Nature medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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Who cites it
52 citing papers in PubMed, 94 citations in OpenAlex.
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- Smad7-based biologic targeting epidermis and stroma promotes healing of diabetic wounds in mice and pigs.Nature communications · 2026Article
- Experimental study on the influence of PDA-modified PDMS on the biological behavior of mouse fibroblasts.Scientific reports · 2026Article
- Wumei extract modulates inflammation and oral microbiota for radiation-induced oral mucositis.Frontiers in microbiology · 2026Article
- Metabolic support protects mucosa from ferroptosis in radiation-induced mucositis.Nature communications · 2025Article
- Gold nanoparticles as innovative therapeutics for oral mucositis: A review of current evidence.Drug delivery and translational research · 2025Review
- Unraveling the complexity of radiotherapy- and chemotherapy-induced oral mucositis: insights into pathogenesis and intervention strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Review
- Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer.Molecular cancer therapeutics · 2024Article
- Smad7 in the hippocampus contributes to memory impairment in aged mice after anesthesia and surgery.Journal of neuroinflammation · 2023Article
- The science of mucositis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis.International journal of radiation oncology, biology, physics · 2022Article
- Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer.Nature reviews. Clinical oncology · 2022Review
- Inhibition of CtBP-Regulated Proinflammatory Gene Transcription Attenuates Psoriatic Skin Inflammation.The Journal of investigative dermatology · 2022Article
- Role of PLEXIND1/TGFβ Signaling Axis in Pancreatic Ductal Adenocarcinoma Progression Correlates with the Mutational Status ofCancers · 2021Article
- Suppression of epithelial to mesenchymal transition markers in mouse lens by a Smad7-based recombinant protein.Chemico-biological interactions · 2021Article
- Accelerated burn wound healing with photobiomodulation therapy involves activation of endogenous latent TGF-β1.Scientific reports · 2021Article
- Oral microbiota transplantation fights against head and neck radiotherapy-induced oral mucositis in mice.Computational and structural biotechnology journal · 2021Article
- Oral mucositis: the hidden side of cancer therapy.Journal of experimental & clinical cancer research : CR · 2020Review
- Oral Mucositis: An Update on Innate Immunity and New Interventional Targets.Journal of dental research · 2020Review
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 3 countries.
Funding
Abstract
We report that K5.Smad7 mice, which express a Smad7 transgene under the control of a keratin 5 promoter, were resistant to radiation-induced oral mucositis, a painful oral ulceration. In addition to nuclear factor κB (NF-κB) activation, which is known to contribute to oral mucositis, we found activated transforming growth factor β (TGF-β) signaling in cells from this condition. Smad7 dampened both pathways to attenuate inflammation, growth inhibition and apoptosis. Additionally, Smad7 promoted oral epithelial migration to close the wound. Further analyses revealed that TGF-β signaling Smads and their co-repressor C-terminal binding protein 1 (CtBP1) transcriptionally repressed Rac1, and that Smad7 abrogated this repression. Knocking down Rac1 expression in mouse keratinocytes abrogated Smad7-induced migration. Topical application of Smad7 protein conjugated with a cell-permeable Tat tag to oral mucosa showed prophylactic and therapeutic effects on radiation-induced oral mucositis in mice. Thus, we have identified new molecular mechanisms involved in oral mucositis pathogenesis, and our data suggest an alternative therapeutic strategy to block multiple pathological processes in this condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.