ArticleCell cycle (Georgetown, Tex.)2013
MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation.
Article in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- A comprehensive review of histone modifications during mammalian oogenesis and early embryo development.Histochemistry and cell biology · 2025Review
- Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.Environmental health perspectives · 2025Article
- Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes.Journal of assisted reproduction and genetics · 2024Article
- Identification, expression, and artificial selection of silkworm epigenetic modification enzymes.BMC genomics · 2020Article
- H4K20 monomethylation inhibition causes loss of genomic integrity in mouse preimplantation embryos.The Journal of reproduction and development · 2020Article
- A Role for Malignant Brain Tumor Domain-Containing Protein 1 in Human Endometrial Stromal Cell Decidualization.Frontiers in cell and developmental biology · 2020Article
- The Origin of a Coastal Indigenous Horse Breed in China Revealed by Genome-Wide SNP Data.Genes · 2019Article
- Review
- Biological Pathways Leading From ANGPTL8 to Diabetes Mellitus-A Co-expression Network Based Analysis.Frontiers in physiology · 2018Article
- CENP-A regulates chromosome segregation during the first meiosis of mouse oocytes.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Article
- Targeting DNA Repair through Podophyllotoxin and Rutin Formulation in Hematopoietic Radioprotection: AnFrontiers in pharmacology · 2017Article
- Function and regulation mechanism of Chk1 during meiotic maturation in porcine oocytes.Cell cycle (Georgetown, Tex.) · 2017Article
- Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.RNA (New York, N.Y.) · 2016Article
- Rab3A, Rab27A, and Rab35 regulate different events during mouse oocyte meiotic maturation and activation.Histochemistry and cell biology · 2016Article
- H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis.Cell cycle (Georgetown, Tex.) · 2016Article
- Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation.Cell cycle (Georgetown, Tex.) · 2015Article
- Casein kinase 1 (α, δ and ε) localize at the spindle poles, but may not be essential for mammalian oocyte meiotic progression.Cell cycle (Georgetown, Tex.) · 2015Article
- Getting the broken blastomere out of development.Cell cycle (Georgetown, Tex.) · 2013Article
- Maternal factors required for oocyte developmental competence in mice: transcriptome analysis of non-surrounded nucleolus (NSN) and surrounded nucleolus (SN) oocytes.Cell cycle (Georgetown, Tex.) · 2013Article
- p53 Protein Evaluation on Spermatozoa DNA in Fertile and Infertile Males.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
H4K20me1 is a critical histone lysine methyl modification in eukaryotes. It is recognized and "read" by various histone lysine methyl modification binding proteins. In this study, the function of MBTD1, a member of the Polycomb protein family containing four MBT domains, was comprehensively studied in mouse oocyte meiotic maturation. The results showed that depletion of MBTD1 caused reduced expression of histone lysine methyl transferase Pr-Set7 and H4K20me1 as well as increased oocyte arrest at the GV stage. Increased γH2AX foci were formed, and DNA damage repair checkpoint protein 53BP1 was downregulated. Furthermore, depletion of MBTD1 activated the cell cycle checkpoint protein Chk1 and downregulated the expression of cyclin B1 and cdc2. MBTD1 knockdown also affected chromosome configuration in GV stage oocytes and chromosome alignment at the MII stage. All these phenotypes were reproduced when the H4K20 methyl transferase Pr-Set7 was depleted. Co-IP demonstrated that MBTD1 was correlated with Pr-Set7 in mouse oocytes. Our results demonstrate that MBTD1 is associated with Pr-Set7 to stabilize H4K20me1 in mouse oocyte meiotic maturation.
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