Evidence map›Paper›PMID 23475069›Full record

ReviewCellular and molecular life sciences : CMLS2013

Vascular growth factors in neuropsychiatry.

Samuel S Newton, Neil M Fournier, Ronald S Duman

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Genome-wide methylome-based molecular pathologies associated with depression and suicide.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  4. Common susceptibility variants ofGeneral psychiatry · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Carbamoylated erythropoietin produces antidepressant-like effects in male and female mice.Progress in neuro-psychopharmacology & biological psychiatry · 2020
    Article
  9. Determination of Serum Vascular Endothelial Growth Factor Levels in Attention Deficit Hyperactivity Disorder: A Case Control Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Regeneration in the nervous system with erythropoietin.Frontiers in bioscience (Landmark edition) · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Samuel S NewtonDepartments of Psychiatry and Neurobiology, Laboratory of Molecular Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA. samuel.sathyanesan@yale.edu
Neil M Fournier
Ronald S Duman
Yale University · US

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI Marina R Picciotto · 2004 to 2026
$37.1M
SCHIZOPHRENIAP01MH025642 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 1985 to 2006
$8.4M
Antidepressants: Signal Transduction and Gene ExpressionR37MH045481 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 2005 to 2014
$3.5M
ANTIDEPRESSANTS AND SIGNAL TRANSDUCTION IN BRAINR01MH045481 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 1995 to 2004
$1.3M
ANTIDEPRESSANTS: SIGNAL TRANSDUCTION AND GENE EXPRESSIONR29MH045481 · NIMH · YALE UNIVERSITY · PI DUMAN, RONALD S. · 1989 to 1993
–
CIHRNIDA NIH HHS P30 DA018343NIMH NIH HHS 2 P01 MH25642NIMH NIH HHS MH45481NIMH NIH HHS P01 MH025642NIMH NIH HHS R01 MH045481NIMH NIH HHS R37 MH045481
6 · The paper itself

Abstract

Recent advances in understanding the cellular and molecular basis of psychiatric illnesses have shed light on the important role played by trophic factors in modulating functional parameters associated with disease causality and drug action. Disease mechanisms are now thought to involve multiple cell types, including neurons and endothelial cells. These functionally distinct but interactively coupled cell types engage in cellular cross talk via shared and common signaling molecules. Dysregulation in their cellular signaling pathways influences brain function and alters behavioral performance. Multifunctional trophic factors such as VEGF and EPO that possess both neurotrophic and angiogenic actions are of particular interest due to their ability to rescue structural and plasticity deficits in neurons and vasculature. Obtaining insight into the behavioral, cellular and molecular actions of multi-functional trophic factors has the potential to open new and transformative therapeutic approaches.

Indexed as

AnimalsAntidepressive AgentsAstrocytesBehavior, AnimalBiomimeticsCognition DisordersDepressionDisease Models, AnimalEndothelial CellsErythropoietinHumansNeuronsVascular Endothelial Growth FactorsAntidepressive AgentsErythropoietinVascular Endothelial Growth Factors

Identifiers

PMID23475069
PMCPMC3951730
OpenAlexW2083227916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.