Evidence map›Paper›PMID 23475065›Full record

ReviewCellular and molecular life sciences : CMLS2013

Neurovascular development and links to disease.

Christiana Ruhrberg, Victoria L Bautch

Abstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. The Beauty and Complexity of Blood Vessel Patterning.Cold Spring Harbor perspectives in medicine · 2022
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Fluid transport in the brain.Physiological reviews · 2022
    Review
  17. The Embryonic Mouse Hindbrain Model to Study Sprouting Angiogenesis In Vivo.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christiana RuhrbergUCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK. c.ruhrberg@ucl.ac.uk
Victoria L Bautch

Funding

MOLECULAR CONTROL OF ANGIOGENESISR01HL043174 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAUTCH, VICTORIA L · 1989 to 2017
$4.7M
Mechanisms of neovascularization in response to ischemiaR01HL117256 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAUTCH, VICTORIA L · 2014 to 2017
$1.5M
Centrosome Mis-Regulation and Blood Vessel FunctionR01HL116719 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BAUTCH, VICTORIA L · 2013 to 2016
$1.5M
Shortened sleep and food motivation: hypothalamic and striatal substratesR01HL086465 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BENCA, RUTH M · 2006 to 2009
$1.4M
NHLBI NIH HHS HL86465NHLBI NIH HHS R01 HL043174NHLBI NIH HHS R01 HL086465NHLBI NIH HHS R01 HL116719NHLBI NIH HHS R01 HL117256NHLBI NIH HHS R01 HL43174Wellcome Trust 095623Wellcome Trust 095623/Z/11/Z
6 · The paper itself

Abstract

The developing central nervous system (CNS) is vascularized via ingression of blood vessels from the outside as the neural tissue expands. This angiogenic process occurs without perturbing CNS architecture due to exquisite cross-talk between the neural compartment and invading blood vessels. Subsequently, this intimate relationship also promotes the formation of the neurovascular unit that underlies the blood-brain barrier and regulates blood flow to match brain activity. This review provides a historical perspective on research into CNS blood vessel growth and patterning, discusses current models used to study CNS angiogenesis, and provides an overview of the cellular and molecular mechanisms that promote blood vessel growth and maturation. Finally, we highlight the significance of these mechanisms for two different types of neurovascular CNS disease.

Indexed as

AnimalsBlood-Brain BarrierBrain DiseasesCentral Nervous SystemHumansNeoplasmsNeovascularization, PathologicNeuropilinsRetinaRhombencephalonSemaphorinsVascular Endothelial Growth Factor ANeuropilinsSemaphorinsVascular Endothelial Growth Factor A

Identifiers

PMID23475065
PMCPMC3632722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.