ArticleThe Journal of reproduction and development2013
Nicotinamide: a class III HDACi delays in vitro aging of mouse oocytes.
Article in The Journal of reproduction and development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- The dynamics of DNA methylation, histone methylation and acetylation during oocyte aging in mammalian species and possible interventions to regulate them.Journal of assisted reproduction and genetics · 2025Review
- Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases.Biochemistry and biophysics reports · 2024Review
- Can Nicotinamide Adenine Dinucleotide (NADAnimals : an open access journal from MDPI · 2024Review
- Impact of NAD+ metabolism on ovarian aging.Immunity & ageing : I & A · 2023Review
- NADThe Journal of reproduction and development · 2022Review
- KAT6A regulates stemness of aging bone marrow-derived mesenchymal stem cells through Nrf2/ARE signaling pathway.Stem cell research & therapy · 2021Article
- Article
- New cellular imaging of oocytes and preimplantation embryos using Lumitein™: Evaluation of oocyte quality and new information on protein dynamics within the perivitelline space during the one-cell oocyte stage in mice.The Journal of reproduction and development · 2020Article
- Imperatorin Ameliorates the Aging-Associated Porcine Oocyte Meiotic Spindle Defects by Reducing Oxidative Stress and Protecting Mitochondrial Function.Frontiers in cell and developmental biology · 2020Article
- Dietary Nutrients Mediate Intestinal Host Defense Peptide Expression.Advances in nutrition (Bethesda, Md.) · 2020Review
- Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.Human reproduction (Oxford, England) · 2016Article
- Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1.Scientific reports · 2015Article
- Prospects for the development of epigenetic drugs for CNS conditions.Nature reviews. Drug discovery · 2015Review
- Oocyte ageing and epigenetics.Reproduction (Cambridge, England) · 2015Review
- Article
- Abnormal lysine acetylation with postovulatory oocyte aging.Reproductive medicine and biology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postovulatory mammalian oocyte developmental potential decreases with aging in vivo and in vitro. Aging oocytes typically show cellular fragmentation and chromosome scattering with an abnormally shaped spindle over time. Previously, it was shown that histone acetylation in the mouse oocyte increased during aging and that treatment with trichostatin A (TSA), an inhibitor for class I and II histone deacetylases (HDACs), enhanced the acetylation, that is, aging. In this study, we examined the effect of nicotinamide (NAM), an inhibitor for class III HDACs, on in vitro aging of mouse oocytes as well as TSA. We found that treatment with NAM significantly inhibited cellular fragmentation, spindle elongation and astral microtubules up to 48 h of culture. Although presence of TSA partially inhibited cellular fragmentation and spindle elongation up to 36 h of culture, treatment with TSA induced chromosome scattering at 24 h of culture and more severe cellular fragmentation at 48 h of culture. Further, we found that α-tubulin, a nonhistone protein, increased acetylation during aging, suggesting that not only histone but nonhistone protein acetylation may also increase with oocyte aging. Thus, these data indicate that protein acetylation is abnormally regulated in aging oocytes, which are associated with a variety of aging phenotypes, and that class I/II and class III HDACs may play distinct roles in aging oocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.