ArticleRetina (Philadelphia, Pa.)2013
Optical coherence tomography-based correlation between choroidal thickness and drusen load in dry age-related macular degeneration.
Article in Retina (Philadelphia, Pa.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Association between Baseline Subfoveal Choroidal Thickness and Anatomical and Functional Outcomes in Geographic Atrophy.Ophthalmology science · 2026Article
- Influence of Clinical and Genetic Factors on the Progression of Age-Related Macular Degeneration: A 3-Year Follow-Up.Journal of clinical medicine · 2023Article
- The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective.Cellular and molecular life sciences : CMLS · 2020Review
- Retinal dystrophy and subretinal drusenoid deposits in female choroideremia carriers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3.Investigative ophthalmology & visual science · 2017Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Molecular response of chorioretinal endothelial cells to complement injury: implications for macular degeneration.The Journal of pathology · 2016Article
- Structural and biochemical analyses of choroidal thickness in human donor eyes.Investigative ophthalmology & visual science · 2014Article
- Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration.American journal of ophthalmology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeSpectral domain optical coherence tomography can be used to measure both choroidal thickness and drusen load. The authors conducted an exploratory study using spectral domain optical coherence tomography to determine if a correlation between choroidal thickness and drusen load exists in patients with dry age-related macular degeneration.
methodsForty-four patients with dry age-related macular degeneration were recruited. The drusen area and volume were determined using the automated software algorithm of the spectral domain optical coherence tomography device, and choroidal thickness was measured using enhanced depth imaging. Correlations were determined using multivariable and univariable analyses.
resultsThe authors found an inverse correlation between choroidal thickness and drusen load (r = -0.35, P = 0.04). Drusen load was also correlated with visual acuity (r = 0.32, P = 0.04). A correlation between choroidal thickness and visual acuity was suggested (r = -0.22, P = 0.21).
conclusionSpectral domain optical coherence tomography can be used to assess the correlation between drusen load and choroidal thickness, both of which show a relationship with visual acuity. The measurement of these outcomes may serve as important outcome parameters in routine clinical care and in clinical trials for patients with dry age-related macular degeneration.
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