Evidence map›Paper›PMID 23474232›Full record

ReviewCurrent opinion in biotechnology2013

Vaccine design: emerging concepts and renewed optimism.

Sebastian K Grimm, Margaret E Ackerman

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Predicting epitopes for vaccine development using bioinformatics tools.Therapeutic advances in vaccines and immunotherapy · 2022
    Review
  3. Article
  4. Biomimetic Nanotechnology toward Personalized Vaccines.Advanced materials (Deerfield Beach, Fla.) · 2020
    Review
  5. Immunoinformatics Approach to Design a Novel Epitope-Based Oral Vaccine AgainstJournal of computational biology : a journal of computational molecular cell biology · 2019
    Article
  6. Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization.Journal of controlled release : official journal of the Controlled Release Society · 2019
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Metabolomics in the fight against malaria.Memorias do Instituto Oswaldo Cruz · 2014
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sebastian K GrimmThayer School of Engineering, Dartmouth College, NH, USA.
Margaret E Ackerman

Funding

Applying High-Performance Protein Engineering Tools to HIV Immunogen DesignR01AI102691 · NIAID · DARTMOUTH COLLEGE · PI ACKERMAN, MARGARET E · 2012 to 2015
$2.2M
NIAID NIH HHS 1R01AI102691NIAID NIH HHS R01 AI102691
6 · The paper itself

Abstract

Arguably, vaccination represents the single most effective medical intervention ever developed. Yet, vaccines have failed to provide any or adequate protection against some of the most significant global diseases. The pathogens responsible for these vaccine-recalcitrant diseases have properties that allow them to evade immune surveillance and misdirect or eliminate the immune response. However, genomic and systems biology tools, novel adjuvants and delivery systems, and refined molecular insight into protective immunity have started to redefine the landscape, and results from recent efficacy trials of HIV and malaria vaccines have instilled hope that another golden age of vaccines may be on the horizon.

Indexed as

Adjuvants, ImmunologicAIDS VaccinesAnimalsAntigen PresentationB-LymphocytesDrug Delivery SystemsHumansImmunity, InnateImmunodominant EpitopesMalaria VaccinesPrecision MedicineSystems BiologyT-LymphocytesVaccinesAdjuvants, ImmunologicAIDS VaccinesImmunodominant EpitopesMalaria VaccinesVaccines

Identifiers

PMID23474232
PMCPMC3696422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.