ReviewPulmonary pharmacology & therapeutics2013
Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels.
Review in Pulmonary pharmacology & therapeutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Modulation of TRPV-1 by prostaglandin-EScientific reports · 2020Trial
- Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α-TRPV1 pathway.Frontiers in pharmacology · 2026Article
- The efficacy of ophiopogonanone B in treating the cough in mice infected withFrontiers in pharmacology · 2025Article
- Neural Mechanisms Underlying the Coughing Reflex.Neuroscience bulletin · 2023Review
- Association of lower plasma citric acid with prolonged cough: the Nagahama study.Scientific reports · 2023Article
- TRPV4 Promotes Metastasis in Melanoma by Regulating Cell Motility through Cytoskeletal Rearrangement.International journal of molecular sciences · 2022Article
- Review
- WAO-ARIA consensus on chronic cough - Part 1: Role of TRP channels in neurogenic inflammation of cough neuronal pathways.The World Allergy Organization journal · 2021Review
- Prostaglandin ERespiratory research · 2021Article
- Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases.Frontiers in pharmacology · 2021Review
- The Cough Reflex: The Janus of Respiratory Medicine.Frontiers in physiology · 2021Review
- Exploring the 'cold/hot' properties of traditional Chinese medicine by cell temperature measurement.Pharmaceutical biology · 2020Article
- Methods for assessing cough sensitivity.Journal of thoracic disease · 2020Review
- Upper Airway Cough Syndrome in Pathogenesis of Chronic Cough.Physiological research · 2020Review
- Upper Respiratory Tract Infection-Associated Acute Cough and the Urge to Cough: New Insights for Clinical Practice.Pediatric allergy, immunology, and pulmonology · 2020Review
- Mechanisms underlying the stimulatory effect of inhaled sulfur dioxide on vagal bronchopulmonary C-fibres.The Journal of physiology · 2020Article
- Effects Of Heat-Conduction Dry Needling Therapy On TRPV1 Channel In Rats.Journal of pain research · 2019Article
- The emerging role of transient receptor potential channels in chronic lung disease.The European respiratory journal · 2017Review
- Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?Pharmaceuticals (Basel, Switzerland) · 2016Review
- TRPV1 and TRPM8 in Treatment of Chronic Cough.Pharmaceuticals (Basel, Switzerland) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cough is a protective reflex and defence mechanism in healthy individuals, which helps clear excessive secretions and foreign material from the lungs. Cough often presents as the first and most persistent symptom of many respiratory diseases and some non-respiratory disorders, but can also be idiopathic, and is a common respiratory complaint for which medical attention is sought. Chronic cough of various aetiologies is a regular presentation to specialist respiratory clinics, and is reported as a troublesome symptom by a significant proportion of the population. Despite this, the treatment options for cough are limited. The lack of effective anti-tussives likely stems from our incomplete understanding of how the tussive reflex is mediated. However, research over the last decade has begun to shed some light on the mechanisms which provoke cough, and may ultimately provide us with better anti-tussive therapies. This review will focus on the in vitro and in vivo models that are currently used to further our understanding of the sensory innervation of the respiratory tract, and how these nerves are involved in controlling the cough response. Central to this are the Transient Receptor Potential (TRP) ion channels, a family of polymodal receptors that can be activated by such diverse stimuli as chemicals, temperature, osmotic stress, and mechanical perturbation. These ion channels are thought to be molecular pain integrators and targets for novel analgesic agents for the treatment of various pain disorders but some are also being developed as anti-tussives.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.