ArticleBrain, behavior, and immunity2013
Impaired leukocyte trafficking and skin inflammatory responses in hamsters lacking a functional circadian system.
Article in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Short- and long-wavelength lights disrupt endocrine signalling but not immune function in a nocturnal marsupial.Conservation physiology · 2025Article
- The identification of diurnal variations on circulating immune cells by finger prick blood sampling in small sample sizes: a pilot study.Laboratory medicine · 2024Article
- Identification of key circadian rhythm genes in skin aging based on bioinformatics and machine learning.Aging · 2023Article
- Brain Dopamine-Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects.International journal of molecular sciences · 2023Review
- Transcriptome analyses of nine endocrine tissues identifies organism-wide transcript distribution and structure in the Siberian hamster.Scientific reports · 2022Article
- Circadian immune circuits.The Journal of experimental medicine · 2021Review
- Suppression of Circadian Timing and Its Impact on the Hippocampus.Frontiers in neuroscience · 2021Review
- Circadian control of interferon-sensitive gene expression in murine skin.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Chronobiological Influence Over Cardiovascular Function: The Good, the Bad, and the Ugly.Circulation research · 2020Review
- Exposure to dim light at night prior to conception attenuates offspring innate immune responses.PloS one · 2020Article
- Circadian integration of inflammation and glucocorticoid actions: Implications for the cochlea.Hearing research · 2019Review
- Clocking in to immunity.Nature reviews. Immunology · 2018Review
- Circadian rhythms accelerate wound healing in female Siberian hamsters.Physiology & behavior · 2017Article
- The circadian clock in skin: implications for adult stem cells, tissue regeneration, cancer, aging, and immunity.Journal of biological rhythms · 2015Review
- Pineal melatonin is a circadian time-giver for leptin rhythm in Syrian hamsters.Frontiers in neuroscience · 2015Article
- Circadian arrhythmia dysregulates emotional behaviors in aged Siberian hamsters.Behavioural brain research · 2014Article
- Cell-autonomous iodothyronine deiodinase expression mediates seasonal plasticity in immune function.Brain, behavior, and immunity · 2014Article
- Regulation of Intestinal Immune Responses through TLR Activation: Implications for Pro- and Prebiotics.Frontiers in immunology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The immune system is under strong circadian control, and circadian desynchrony is a risk factor for metabolic disorders, inflammatory responses and cancer. Signaling pathways that maintain circadian rhythms (CRs) in immune function in vivo, and the mechanisms by which circadian desynchrony impairs immune function, remain to be fully identified. These experiments tested the hypothesis that the hypothalamic circadian pacemaker in the suprachiasmatic nucleus (SCN) drives CRs in the immune system, using a non-invasive model of SCN circadian arrhythmia. Robust CRs in blood leukocyte trafficking, with a peak during the early light phase (ZT4) and nadir in the early dark phase (ZT18), were absent in arrhythmic hamsters, as were CRs in spleen clock gene (per1, bmal1) expression, indicating that a functional pacemaker in the SCN is required for the generation of CRs in leukocyte trafficking and for driving peripheral clocks in secondary lymphoid organs. Pinealectomy was without effect on CRs in leukocyte trafficking, but abolished CRs in spleen clock gene expression, indicating that nocturnal melatonin secretion is necessary for communicating circadian time information to the spleen. CRs in trafficking of antigen presenting cells (CD11c(+) dendritic cells) in the skin were abolished, and antigen-specific delayed-type hypersensitivity skin inflammatory responses were markedly impaired in arrhythmic hamsters. The SCN drives robust CRs in leukocyte trafficking and lymphoid clock gene expression; the latter of which is not expressed in the absence of melatonin. Robust entrainment of the circadian pacemaker provides a signal critical to diurnal rhythms in immunosurveilliance and optimal memory T-cell dependent immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.