ArticlePhysiology & behavior2013
Prior access to a sweet is more protective against cocaine self-administration in female rats than in male rats.
Article in Physiology & behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Sweet taste liking is associated with subjective response to amphetamine in women but not men.Psychopharmacology · 2017Trial
- Effect of acute treatment with the glucagon-like peptide-1 receptor agonist, liraglutide, and estrus phase on cue- and drug-induced fentanyl seeking in female rats.Behavioural pharmacology · 2025Article
- Effects of Serial Polydrug Use on the Rewarding and Aversive Effects of the Novel Synthetic Cathinone Eutylone.Brain sciences · 2023Article
- Impact of the Aversive Effects of Drugs on Their Use and Abuse.Behavioural neurology · 2022Review
- Abuse potential and toxicity of the synthetic cathinones (i.e., "Bath salts").Neuroscience and biobehavioral reviews · 2020Review
- Exercise or saccharin during abstinence block estrus-induced increases in nicotine-seeking.Physiology & behavior · 2019Article
- Female rats exhibit less avoidance than male rats of a cocaine-, but not a morphine-paired, saccharin cue.Brain research bulletin · 2018Article
- Altered reward sensitivity in female offspring of cocaine-exposed fathers.Behavioural brain research · 2017Article
- The Affective Properties of Synthetic Cathinones: Role of Reward and Aversion in Their Abuse.Current topics in behavioral neurosciences · 2017Review
- Sex Differences in the Motivational Contrast between Sucrose and Cocaine in Rats.Journal of drug design and research · 2017Article
- Sex and menstrual cycle effects on chronic oral cocaine self-administration in rhesus monkeys: Effects of a nondrug alternative reward.Psychopharmacology · 2016Article
- The role of dose and restriction state on morphine-, cocaine-, and LiCl-induced suppression of saccharin intake: A comprehensive analysis.Physiology & behavior · 2016Article
- Early avoidance of a heroin-paired taste-cue and subsequent addiction-like behavior in rats.Brain research bulletin · 2016Article
- Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats.Psychopharmacology · 2016Article
- Low expression of D2R and Wntless correlates with high motivation for heroin.Behavioral neuroscience · 2015Article
- Greater avoidance of a heroin-paired taste cue is associated with greater escalation of heroin self-administration in rats.Behavioral neuroscience · 2015Article
- Examination of cocaine dose in a preclinical model of natural reward devaluation by cocaine.Behavioural pharmacology · 2015Article
- Cocaine-induced suppression of saccharin intake and morphine modulation of Ca²⁺ channel currents in sensory neurons of OPRM1 A118G mice.Physiology & behavior · 2015Article
- Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments.Frontiers in psychiatry · 2015Review
- Once is too much: conditioned aversion develops immediately and predicts future cocaine self-administration behavior in rats.Behavioral neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It is well established that female rats are more sensitive than male rats to the reinforcing effects of cocaine (Lynch, 2008 [42] for review). We hypothesized that greater preference for cocaine would support greater avoidance of a cocaine-paired taste cue in female vs. male rats. Moreover, at least in male rats, greater avoidance of the taste cue is associated with greater cocaine self-administration (Grigson and Twining, 2002 [3]). Thus, we anticipated that female rats would not only demonstrate greater avoidance of the drug-paired taste cue, but greater drug-taking as well. We tested these hypotheses by examining avoidance of a saccharin cue in male and female rats following several pairings with self-administered saline or cocaine (0.16, 0.33, or 0.66 mg/infusion). Contrary to expectations, the results showed that female rats exhibited less avoidance of the cocaine-associated saccharin cue than male rats and self-administered less, rather than more, cocaine, Thus, while female rats reportedly take more drug than male rats when the drug is presented in the absence of an alternative reward, they take less drug than male rats when the opportunity to self-administer cocaine is preceded by access to a palatable sweet. Females, then, may not simply be more sensitive to the rewarding properties of drug, but also to the reinforcing properties of natural rewards and this increase in sensitivity to sweets may serve to protect against drug-taking behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.