SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2013
Dementia severity and weight loss: a comparison across eight cohorts. The 10/66 study.
Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of total diet replacement programs on mental well-being: A systematic review with meta-analyses.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Different hypothalamic regions in late-onset Alzheimer's disease and aging: involvement and links with cognitive and non-cognitive features.GeroScience · 2026Article
- The association between cognitive domains and suicidal ideation in patients with mild dementia: the crucial role of judgement domain.BMC geriatrics · 2025Article
- Population intervention models of racial ethnic disparities in cognitive outcomes from cardiometabolic risk factors - HABS-HD.Alzheimer's research & therapy · 2025Article
- Brain activation generated by periodontal initial treatment.Journal of dental sciences · 2025Article
- Nutrition: A non-negligible factor in the pathogenesis and treatment of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Associations of body mass index and waist circumference with all cause mortality in the oldest old with cognitive impairment: a prospective cohort study.Frontiers in nutrition · 2025Article
- The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Temporal trends and disparities of population attributable fractions of modifiable risk factors for dementia in China: a time-series study of the China health and retirement longitudinal study (2011-2018).The Lancet regional health. Western Pacific · 2024Article
- Should dietary restrictions be imposed on Alzheimer's Disease patients affected by type 2 diabetes?Dialogues in clinical neuroscience · 2024Article
- A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease.Heliyon · 2023Review
- Article
- Remote Monitoring of Physiology in People Living With Dementia: An Observational Cohort Study.JMIR aging · 2023Article
- Association between physical activity, growth differentiation factor 15 and bodyweight in older adults: A longitudinal mediation analysis.Journal of cachexia, sarcopenia and muscle · 2023Article
- Weight Change and Neuropsychiatric Symptoms in Alzheimer's Disease and Frontotemporal Dementia: Associations with Cognitive Decline.Journal of Alzheimer's disease reports · 2023Article
- Association of Nonalcoholic Fatty Liver Disease and Fibrosis With Incident Dementia and Cognition: The Rotterdam Study.Neurology · 2022Article
- Glucose-Lowering Medications and Post-Dementia Survival in Patients with Diabetes and Dementia.Journal of Alzheimer's disease : JAD · 2022Article
- Association of weight change with cerebrospinal fluid biomarkers and amyloid positron emission tomography in preclinical Alzheimer's disease.Alzheimer's research & therapy · 2021Article
- Factors associated with unintentional weight loss among older adults in a geriatric outpatient clinic of university hospital.PloS one · 2021Article
- Severe Dementia Predicts Weight Loss by the Time of Death.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundWe aimed to investigate the association between dementia severity and weight loss in countries with low and middle incomes, where most prevalent cases reside.
methodsCross-sectional catchment area surveys were performed in Cuba, Mexico, Venezuela, Peru, Dominican Republic, Puerto Rico, China, and India. In 16,538 older adults (≥65 years of age), significant weight loss was self-reported and confirmed by an informant. We conducted neuropsychological testing and clinical and neurological assessments. Dementia severity was determined by applying a validated algorithm and was quantified by the Clinical Dementia Rating Scale.
resultsThe characteristics of those who reported weight loss varied across countries. In Poisson models, after controlling for relevant covariates and for waist and arm circumferences, dementia severity was associated with reported weight loss (pooled prevalence ratios [95% confidence intervals {CI}] 2.19 [1.98, 2.41]; 3.81 [3.35, 4.33]; and 5.18 [4.41, 6.10] for CDR 0.5, 1, and 2/3, respectively, compared with CDR 0). The association increased linearly through stages of dementia severity in all countries (P for trend < .001), and between-country heterogeneity was minimal.
conclusionsWe found a strong gradient effect in the direct association between dementia severity and reported weight loss, homogeneous across sites from eight countries, consistent with mechanistic data on the role of neurodegenerative processes on energy balance and with dietary changes due to disease severity. Considering the well-recognized effect of weight loss on morbidity and mortality and the large number affected by dementia in less resourced countries, amelioration of weight loss in dementia patients should be considered with priority in these settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.