ReviewNeuropharmacology2014
Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans.
Review in Neuropharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01721473 (Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers), which is not on this map. Cited by 79 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 160 citations in OpenAlex.
- Chronic cigarette smoking is linked with structural alterations in brain regions showing acute nicotinic drug-induced functional modulations.Behavioral and brain functions : BBF · 2016Pooled it
- Neurobiological impact of nicotinic acetylcholine receptor agonists: an activation likelihood estimation meta-analysis of pharmacologic neuroimaging studies.Biological psychiatry · 2015Pooled it
- Effects of nicotine on smooth pursuit eye movements in healthy non-smokers.Psychopharmacology · 2019Trial
- COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers.Genes, brain, and behavior · 2015Trial
- Synthetic cooling agents enhance nicotine reinforcement and mesolimbic dopamine signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Describing ZYN-Related Content on TikTok: Content Analysis.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- Associations Between Nicotine Metabolites and Serum Neurofilament Light Chain Levels in the General Population.Chronic diseases and translational medicine · 2025Article
- Association between nicotine-dependent patients and delirium in intensive care units: a retrospective cohort study using a large clinical database.BMC psychiatry · 2025Article
- "I just wish vaping wasn't a thing": an Australian qualitative study of parental concerns and perceptions towards adolescent vaping.BMC public health · 2025Article
- How "Light" Is "Light Smoking"? On the Cognitive Power of Nicotine Dependence.Behavioral sciences (Basel, Switzerland) · 2024Article
- Interrelated involvement of the endocannabinoid/endovanilloid (TRPV1) systems and epigenetic processes in anxiety- and working memory impairment-related behavioural effects of nicotine as a stressor.Addiction biology · 2024Article
- The effect of e-cigarettes on cognitive function: a scoping review.Psychopharmacology · 2024Article
- Machine Learning of Functional Connectivity to Biotype Alcohol and Nicotine Use Disorders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Childhood Trauma, Emotional Awareness, and Neural Correlates of Long-Term Nicotine Smoking.JAMA network open · 2024Article
- Application of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T.PloS one · 2024Article
- Sex difference in association between cognitive and P50 deficits in patients with chronic schizophrenia.Archives of women's mental health · 2023Article
- Longstanding smoking associated with frontal brain lobe atrophy: a 32-year follow-up study in women.BMJ open · 2023Article
- Persistent impacts of smoking on resting-state EEG in male chronic smokers and past-smokers with 20 years of abstinence.Scientific reports · 2023Article
- Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Demographics, clinical characteristics and cognitive symptoms of heavy smokers and non-heavy smokers in Chinese male patients with chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Substantial evidence demonstrates both nicotine's addiction liability and its cognition-enhancing effects. However, the neurobiological mechanisms underlying nicotine's impact on brain function and behavior remain incompletely understood. Elucidation of these mechanisms is of high clinical importance and may lead to improved therapeutics for smoking cessation as well as for a number of cognitive disorders such as schizophrenia. Neuroimaging techniques such as positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI), which make it possible to study the actions of nicotine in the human brain in vivo, play an increasingly important role in identifying these dual mechanisms of action. In this review, we summarize the current state of knowledge and discuss outstanding questions and future directions in human neuroimaging research on nicotine and tobacco. This research spans from receptor-level PET and SPECT studies demonstrating nicotine occupancy at nicotinic acetylcholine receptors (nAChRs) and upregulation of nAChRs induced by chronic smoking; through nicotine's interactions with the mesocorticolimbic dopamine system believed to mediate nicotine's reinforcing effects leading to dependence; to functional activity and connectivity fMRI studies documenting nicotine's complex behavioral and cognitive effects manifest by its actions on large-scale brain networks engaged both during task performance and at rest. This article is part of the Special Issue Section entitled 'Neuroimaging in Neuropharmacology'.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.