ArticleBrain research2013
Functional disconnection of axonal fibers generated by high frequency stimulation in the hippocampal CA1 region in-vivo.
Article in Brain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Long-term treatment with responsive brain stimulation in adults with refractory partial seizures.Neurology · 2015Trial
- Nonlinear analysis of neuronal firing modulated by sinusoidal stimulation at axons in rat hippocampus.Frontiers in computational neuroscience · 2024Article
- Activating Interneurons in Local Inhibitory Circuits by High-Frequency Stimulations at the Efferent Fibers of Pyramidal Neurons in Rat Hippocampal CA1 Region.Brain sciences · 2022Article
- The cortical evoked potential corresponds with deep brain stimulation efficacy in rats.Journal of neurophysiology · 2022Article
- Suppression of Neuronal Firing Following Antidromic High-Frequency Stimulations on the Neuronal Axons in Rat Hippocampal CA1 Region.Frontiers in neuroscience · 2022Article
- [Design and application of neural electrical stimulation system with time-varying parameters].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Adjust Neuronal Reactions to Pulses of High-Frequency Stimulation with Designed Inter-Pulse-Intervals in Rat Hippocampus In Vivo.Brain sciences · 2021Article
- Different effects of monophasic pulses and biphasic pulses applied by a bipolar stimulation electrode in the rat hippocampal CA1 region.Biomedical engineering online · 2021Article
- Suppressing synchronous firing of epileptiform activity by high-frequency stimulation of afferent fibers in rat hippocampus.CNS neuroscience & therapeutics · 2021Article
- The Appearance Order of Varying Intervals Introduces Extra Modulation Effects on Neuronal Firing Through Non-linear Dynamics of Sodium Channels During High-Frequency Stimulations.Frontiers in neuroscience · 2020Article
- Selective modulation of neuronal firing by pulse stimulations with different frequencies in rat hippocampus.Biomedical engineering online · 2019Article
- [A design of raster plot for illustrating dynamic neuronal activity during deep brain stimulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2019Article
- Comparison and Selection of Current Implantable Anti-Epileptic Devices.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019Review
- Small Changes in Inter-Pulse-Intervals Can Cause Synchronized Neuronal Firing During High-Frequency Stimulations in Rat Hippocampus.Frontiers in neuroscience · 2019Article
- Design of a novel stimulation system with time-varying paradigms for investigating new modes of high frequency stimulation in brain.Biomedical engineering online · 2018Article
- [High frequency stimulations change the phase-locking relationship between neuronal firing and the rhythms of field potentials].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018Article
- Simulation Study of Intermittent Axonal Block and Desynchronization Effect Induced by High-Frequency Stimulation of Electrical Pulses.Frontiers in neuroscience · 2018Article
- Axonal Stimulations With a Higher Frequency Generate More Randomness in Neuronal Firing Rather Than Increase Firing Rates in Rat Hippocampus.Frontiers in neuroscience · 2018Article
- Novel Stimulation Paradigms with Temporally-Varying Parameters to Reduce Synchronous Activity at the Onset of High Frequency Stimulation in Rat Hippocampus.Frontiers in neuroscience · 2017Article
- Somatosensory stimulation suppresses the excitability of pyramidal cells in the hippocampal CA1 region in rats.Neural regeneration research · 2014Article
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4 authors.
Funding
Abstract
High frequency stimulation (HFS) applied in the brain has been shown to be efficient for treating several brain disorders, such as Parkinson's disease and epilepsy. But the mechanisms underlying HFS are not clear. In particular, the effect of HFS on axons has been intriguing since axonal propagation plays an important role in the functional outcome of HFS. In order to study the potential effect of axonal block by HFS in-vivo, both orthodromic- and antidromic-HFS (O-HFS, A-HFS) with biphasic pulses were applied to the hippocampal CA1 region in anaesthetized rats. Changes in the amplitude and latency of orthodromic- and antidromic-population spikes within 1-min long period of stimulation at 50, 100 and 200 Hz HFS were analyzed. The results show that except for a short onset period, activity evoked by O-HFS with a frequency over 100 Hz could not be sustained. For A-HFS at frequencies over 100 Hz, the amplitudes and the latencies of antidromic population spike (APS) greatly decreased and increased respectively. Significantly larger changes in APS latency were observed in HFS than those generated at low frequency, suggesting a suppression of axon conduction by HFS. Furthermore, the CA1 somata remained excitable while failing to respond to excitation from orthodromic or antidromic HFS. Taken together, these results show that HFS produces an axonal block of both afferent and efferent fibers localized to the area of stimulation since it does not affect the excitability of CA1 somata. This effect of HFS on axons causes a functional disconnection of axonal pathways that is reversible and temporary. The reversible disconnection or temporary deafferentation between putative therapeutic targets could have extensive implication for various clinical applications of HFS to treat brain diseases.
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