ArticleJournal of neuroscience methods2013
A method for closed-loop presentation of sensory stimuli conditional on the internal brain-state of awake animals.
Article in Journal of neuroscience methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Pre-stimulus alpha power modulates trial-by-trial variability in theta rhythmic multisensory entrainment strength and theta-induced memory effect.Communications psychology · 2026Article
- Article
- Real-time estimation of phase and amplitude with application to neural data.Scientific reports · 2021Article
- A user-friendly algorithm for adaptive closed-loop phase-locked stimulation.Journal of neuroscience methods · 2021Article
- A circuit for detection of interaural time differences in the nucleus laminaris of turtles.The Journal of experimental biology · 2017Article
- Induced cortical oscillations in turtle cortex are coherent at the mesoscale of population activity, but not at the microscale of the membrane potential of neurons.Journal of neurophysiology · 2017Article
- Network activity influences the subthreshold and spiking visual responses of pyramidal neurons in the three-layer turtle cortex.Journal of neurophysiology · 2017Article
- Adaptation modulates correlated subthreshold response variability in visual cortex.Journal of neurophysiology · 2017Article
- A Framework for the Comparative Assessment of Neuronal Spike Sorting Algorithms towards More Accurate Off-Line and On-Line Microelectrode Arrays Data Analysis.Computational intelligence and neuroscience · 2016Article
- Coherent and intermittent ensemble oscillations emerge from networks of irregular spiking neurons.Journal of neurophysiology · 2016Article
- Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond.Journal of visualized experiments : JoVE · 2015Article
- Searching for collective behavior in a large network of sensory neurons.PLoS computational biology · 2014Article
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Authors and funding
3 authors.
Funding
Abstract
Brain activity often consists of interactions between internal-or on-going-and external-or sensory-activity streams, resulting in complex, distributed patterns of neural activity. Investigation of such interactions could benefit from closed-loop experimental protocols in which one stream can be controlled depending on the state of the other. We describe here methods to present rapid and precisely timed visual stimuli to awake animals, conditional on features of the animal's on-going brain state; those features are the presence, power and phase of oscillations in local field potentials (LFP). The system can process up to 64 channels in real time. We quantified its performance using simulations, synthetic data and animal experiments (chronic recordings in the dorsal cortex of awake turtles). The delay from detection of an oscillation to the onset of a visual stimulus on an LCD screen was 47.5ms and visual-stimulus onset could be locked to the phase of ongoing oscillations at any frequency ≤40Hz. Our software's architecture is flexible, allowing on-the-fly modifications by experimenters and the addition of new closed-loop control and analysis components through plugins. The source code of our system "StimOMatic" is available freely as open-source.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.