Evidence map›Paper›PMID 23473789›Full record

ArticleGene expression patterns : GEP

Expression of cyclin D1, cyclin D2, and N-myc in embryos of the direct developing frog Eleutherodactylus coqui, with a focus on limbs.

Kimberly Nath, Cara Fisher, Richard P Elinson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gene expression patterns : GEP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kimberly NathDepartment of Biological Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Cara Fisher
Richard P Elinson
Duquesne University · US

Funding

Suppression of tadpole limbs: a model for organ size regulationR15HD059070 · NICHD · DUQUESNE UNIVERSITY · PI ELINSON, RICHARD P · 2008 to 2009
$214k
NICHD NIH HHS 1 R15 HD059070-01NICHD NIH HHS R15 HD059070
6 · The paper itself

Abstract

Species of frogs that develop directly have removed the tadpole from their ontogeny and form adult structures precociously. To see whether cell cycle regulators could be involved in this altered embryogenesis, we examined the expression of ccnd1, ccnd2, and mycn in embryos of the direct developing frog, Eleutherodactylus coqui. Notable differences compared to embryos of Xenopus laevis, a species with a tadpole, included prominent expression of ccnd2 in the midbrain and ccnd1 in the mandibular neural crest. The former may contribute to the precocious appearance of the adult-type visual system and the latter to the adult-type jaw. Large domains of ccnd2 and mycn presage the early appearance of limb buds, and ccnd1 and mycn are implicated in digit development.

Indexed as

AnimalsAnuraCyclin D1Cyclin D2Embryonic DevelopmentEmbryo, NonmammalianExtremitiesGene Expression Regulation, DevelopmentalLarvaProto-Oncogene Proteins c-mycXenopus laevisCyclin D1Cyclin D2Proto-Oncogene Proteins c-myc

Identifiers

PMID23473789
PMCPMC3657300
OpenAlexW1973685840

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.