ArticleJournal of chromatography. A2013
Evaluation of a microchip electrophoresis-mass spectrometry platform deploying a pressure-driven make-up flow.
Article in Journal of chromatography. A, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- A microchip electrophoresis-mass spectrometric platform with double cell lysis nano-electrodes for automated single cell analysis.Journal of chromatography. A · 2016Article
- Microfluidic Platform with In-Chip Electrophoresis Coupled to Mass Spectrometry for Monitoring Neurochemical Release from Nerve Cells.Analytical chemistry · 2016Article
- D-serine uptake and release in PC-12 cells measured by chiral microchip electrophoresis-mass spectrometry.ACS chemical neuroscience · 2015Article
- Fast quantification of amino acids by microchip electrophoresis-mass spectrometry.Analytical and bioanalytical chemistry · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Integration of a pressure-driven make-up flow (MUF) into a microchip electrophoresis (MCE) platform in order to facilitate its coupling with electrospray ionization-mass spectrometric detection (ESI-MS) is described. In the glass/PDMS hybrid microchip, a MUF channel was made to intersect with the MCE separation channel at an angle of 45°. The MUF was generated by a syringe pump. Microscopic image results from simulation studies showed that the pressure-driven MUF and the potential-driven electroosmotic flow in the MCE separation channel could be run separately without interfering with each other and mixed well at the joint point by adjusting either the MUF flow rate or the potential applied for MCE separation. The MUF had several desirable functions, including making the start of electrospray easy and cleaning the nanoESI emitter continuously when not spraying. High separation efficiency was achieved with the proposed MCE-nanoESI-MS system in separating an amino acid mixture containing glutamine, serine, threonine, phenylalanine, and glutamic acid. All of them were baseline separated from each other within 3 min. Plate numbers of >10,000 (on a 2.5 cm MCE separation channel) were obtained. The analytical platform also showed a linear response for quantification of DOPA with a detection limit (S/N=3) of 0.10 μM. In addition, on-line derivatization of MCE elutes in order to enhance MS detection sensitivity was easily carried out by adding the tagging reagent into the MUF. These results indicated that the present system might have a good potential in MCE-MS applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.