ArticleBiophysical journal2013
Mathematical modeling of blood clot fragmentation during flow-mediated thrombolysis.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Comparative study on efficacy of thrombolytic protocols: Dual therapy against standard tPA regimen.Biophysical journal · 2025Article
- Effect of Ultrasound on Thrombus debris during Sonothrombolysis in a Microfluidic device.Journal of thrombosis and thrombolysis · 2024Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions.Scientific reports · 2023Article
- Effects of clot contraction on clot degradation: A mathematical and experimental approach.Biophysical journal · 2022Article
- On the Sensitivity Analysis of Porous Finite Element Models for Cerebral Perfusion Estimation.Annals of biomedical engineering · 2021Article
- The Utility and Potential of Mathematical Models in Predicting Fibrinolytic Outcomes.Current opinion in biomedical engineering · 2021Article
- Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles.Scientific reports · 2021Article
- A porous circulation model of the human brain forInterface focus · 2021Article
- In vivo measurement of blood clot mechanics from computational fluid dynamics based on intravital microscopy images.Computers in biology and medicine · 2019Article
- Three-phase Model of Visco-elastic Incompressible Fluid Flow and its Computational Implementation.Communications in computational physics · 2019Article
- Computational Simulations of Thrombolytic Therapy in Acute Ischaemic Stroke.Scientific reports · 2018Article
- An in vitro proof-of-principle study of sonobactericide.Scientific reports · 2018Article
- Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation.PloS one · 2017Article
- Towards a multi-physics modelling framework for thrombolysis under the influence of blood flow.Journal of the Royal Society, Interface · 2015Article
- Thrombolytic efficacy and enzymatic activity of rt-PA-loaded echogenic liposomes.Journal of thrombosis and thrombolysis · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A microscale mathematical model of blood clot dissolution based on coarse-grained molecular dynamics is presented. In the model, a blood clot is assumed to be an assembly of blood cells interconnected with elastic fibrin bonds, which are cleaved either biochemically (bond degradation) or mechanically (bond overstretching) during flow-mediated thrombolysis. The effect of a thrombolytic agent on biochemical bond degradation was modeled phenomenologically by assuming that the decay rate of an individual bond is a function of the remaining noncleaved bonds in the vicinity of that bond (spatial corrosion) and the relative stretching of the bond (deformational corrosion). The results of simulations indicate that the blood clot dissolution process progresses by a blood-flow-promoted removal of clot fragments, the sizes of which are flow-dependent. These findings are in good agreement with the results of our recent optical-microscopy experimental studies on a model of blood clot dissolution, as well as with clinical observations. The findings of this study may contribute to a better understanding of the clot fragmentation process and may therefore also help in designing new, safer thrombolytic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.