Evidence map›Paper›PMID 23473028›Full record

ArticleCell metabolism2013

Xenobiotics and the human gut microbiome: metatranscriptomics reveal the active players.

Luke K Ursell, Rob Knight

Abstract readComment
In one paragraph

Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Potential Pathogens Associated with Colorectal Cancer.Current pharmaceutical biotechnology · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Microbial biotransformations in the human distal gut.British journal of pharmacology · 2018
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Gut microbiome interactions with drug metabolism, efficacy, and toxicity.Translational research : the journal of laboratory and clinical medicine · 2017
    Review
  14. Article
  15. Review
  16. Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Luke K UrsellDepartment of Chemistry & Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA.
Rob Knight

Funding

A Quality Assurance, Coordination and Analysis Center for HMPU01HG004866 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI WHITE, OWEN R · 2008 to 2012
$12.5M
TRAINING IN SIGNAL TRANSDUCTION &CELL CYCLE REGULATIONT32GM008759 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI AHN, NATALIE G. · 2000 to 2020
$5.9M
Predoctoral Training Program in Signaling and Cellular Regulation INCLUDE Down Syndrome SupplementT32GM142607 · NIGMS · UNIVERSITY OF COLORADO · PI Sabrina Leigh Spencer, Tin Tin Su · 2021 to 2026
$3.6M
New Tools for Understanding the Composition and Dynamics of Microbial CommunitiesR01HG004872 · NHGRI · UNIVERSITY OF COLORADO · PI KNIGHT, ROB · 2008 to 2012
$1.8M
Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG004872NHGRI NIH HHS U01 HG004866NIGMS NIH HHS T32 GM008759NIGMS NIH HHS T32 GM142607
6 · The paper itself

Abstract

The human gut microbiome plays an important role in the metabolism of xenobiotics. In a recent issue of Cell, Maurice et al. (2013) identify the active members of the gut microbiome and show how gene-expression profiles change within the gut microbial community in response to antibiotics and host-targeted xenobiotics.

Identifiers

PMID23473028
PMCPMC3641660

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.