Evidence map›Paper›PMID 23473025›Full record

ArticleCell metabolism2013

Novel SIRT1 mutation linked to autoimmune diabetes in humans.

Jing W Hughes, Kevan C Herold

Open access · bronzeAbstract readComment
In one paragraph

Article in Cell metabolism, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jing W HughesDepartments of Immunobiology and Internal Medicine, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA.
Kevan C Herold
Yale University · US

Funding

Phase II Trial of HOKT3gamma 1 (ALA-ALA) in Type 1 DiabetesR01DK057846 · NIDDK · YALE UNIVERSITY · PI Kevan C Herold · 2000 to 2026
$11.1M
Yale Autoimmunity Center of ExcellenceU19AI082713 · NIAID · YALE UNIVERSITY · PI CHO, JUDY H. · 2009 to 2013
$3.6M
Innate and Adaptive Immune Responses in Pre-type 1 DiabetesRC4DK090805 · NIDDK · YALE UNIVERSITY · PI HEROLD, KEVAN C · 2010 to 2010
$399k
Measurement of Beta Cell Death in DiabetesR41DK095639 · NIDDK · L2 DIAGNOSTICS, LLC · PI HEROLD, KEVAN C · 2012 to 2012
$285k
NIAID NIH HHS U19 AI082713NIDDK NIH HHS R01 DK057846NIDDK NIH HHS R41 DK095639NIDDK NIH HHS RC4 DK090805
6 · The paper itself

Abstract

Sirtuins are best known for their role in aging but also regulate many different biological processes. A study in this issue of Cell Metabolism (Biason-Lauber et al., 2013) now identifies a mutation in human SIRT1 causing a familial form of autoimmune diabetes.

Identifiers

PMID23473025
PMCPMC4168898
OpenAlexW2091092468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.