Evidence map›Paper›PMID 23472868›Full record

ArticleCell stem cell2013

Strategies for improving animal models for regenerative medicine.

Jose Cibelli, Marina E Emborg, Darwin J Prockop, Michael Roberts, Gerald Schatten, Mahendra Rao, John Harding, Oleg Mirochnitchenko

Abstract read
In one paragraph

Article in Cell stem cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Contributions of large and agricultural animal models to immunology.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  4. Ex vivo functional whole organ in biomedical research: a review.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. MSC therapy in livestock models.Translational animal science · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jose CibelliMichigan State University, Cellular Reprogramming Laboratory, Department of Animal Science, B270 Anthony Hall, East Lansing, MI 48824, USA.
Marina E Emborg
Darwin J Prockop
Michael Roberts
Gerald Schatten
Mahendra Rao
John Harding
Oleg Mirochnitchenko

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
PRIMATE RESOURCESP01HD047675 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SCHATTEN, GERALD · 2005 to 2010
$15.5M
Preparation and Distribution of Adult Stem CellsP40OD011050 · OD · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI PROCKOP, DARWIN JOHNSON · 2012 to 2017
$6.0M
The Laboratory of Stem Cell BiologyZIAAR041193 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI RAO, MAHENDRA · 2011 to 2014
$3.7M
Induced Pluripotent Stem Cells from Swine: application to genetic modificationR01HD069979 · NICHD · UNIVERSITY OF MISSOURI-COLUMBIA · PI ROBERTS, R. MICHAEL · 2012 to 2016
$1.5M
NICHD NIH HHS P01 HD047675NICHD NIH HHS R01 HD069979NIH HHS P40 OD011050NIH HHS P51 OD011106
6 · The paper itself

Abstract

The field of regenerative medicine is moving toward translation to clinical practice. However, there are still knowledge gaps and safety concerns regarding stem cell-based therapies. Improving large animal models and methods for transplantation, engraftment, and imaging should help address these issues, facilitating eventual use of stem cells in the clinic.

Indexed as

AnimalsModels, AnimalRegenerative MedicineStem CellsStem Cell Transplantation

Identifiers

PMID23472868
PMCPMC4383280

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.