ArticleACS combinatorial science2013
Solution-phase synthesis of a diverse library of benzisoxazoles utilizing the [3 + 2] cycloaddition of in situ-generated nitrile oxides and arynes.
Article in ACS combinatorial science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Substitutional Diversity-Oriented Synthesis and In Vitro Anticancer Activity of Framework-Integrated Estradiol-Benzisoxazole Chimeras.Molecules (Basel, Switzerland) · 2022Article
- Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes.The Journal of organic chemistry · 2019Article
- 1,3- and 1,4-Benzdiyne equivalents for regioselective synthesis of polycyclic heterocycles.Chemical science · 2016Article
- Multifaceted strategy for the synthesis of diverse 2,2'-bithiophene derivatives.Molecules (Basel, Switzerland) · 2015Article
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7 authors.
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Abstract
A library of benzisoxazoles has been synthesized by the [3 + 2] cycloaddition of nitrile oxides with arynes and further diversified by acylation/sulfonylation and palladium-catalyzed coupling processes. The eight key intermediate benzisoxazoles have been prepared by the reaction of o-(trimethylsilyl)aryl triflates and chlorooximes in the presence of CsF in good to excellent yields under mild reaction conditions. These building blocks have been used as the key components of a diverse set of 3,5,6-trisubstituted benzisoxazoles.
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