ReviewProgress in cardiovascular diseases
Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hypotension.
Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Guidelines for the diagnosis and treatment of neurally mediated syncope in children and adolescents (revised 2024).World journal of pediatrics : WJP · 2024Guideline
- Physical manoeuvers as a preventive intervention to manage vasovagal syncope: A systematic review.PloS one · 2019Pooled it
- Implantable loop recorder versus conventional diagnostic workup for unexplained recurrent syncope.The Cochrane database of systematic reviews · 2016Pooled it
- Trial
- Article
- Vasovagal Syncope: A Review of Current and Emerging Therapies for a Common Cardiology Condition.The journal of Tehran Heart Center · 2024Article
- Clinical Associations of Injuries Caused by Vasovagal Syncope: A Cohort Study From a Tertiary Syncope Unit.Journal of the American Heart Association · 2023Article
- Anxiety and Depression as Risk Factors for Vasovagal Syncope and Potential Treatment Targets: A Systematic Review.Cureus · 2022Review
- Analysis of hot trends in research on the association between vitamin D and cardiovascular disease.Frontiers in nutrition · 2022Article
- Dyspnea in Chronic Low Ventricular Preload States.Annals of the American Thoracic Society · 2021Review
- A cost and efficacy analysis of performing arthroscopic excision of wrist ganglions under wide-awake anaesthesia versus general anaesthesia.BMC musculoskeletal disorders · 2020Article
- The effect of level of injury and physical activity on heart rate variability following spinal cord injury.The journal of spinal cord medicine · 2019Article
- Review
- Review
- Autonomic Dysfunction in Cardiology: Pathophysiology, Investigation, and Management.The Canadian journal of cardiology · 2017Review
- PERTINENT DRY NEEDLING CONSIDERATIONS FOR MINIMIZING ADVERSE EFFECTS - PART TWO.International journal of sports physical therapy · 2016Article
- Syncope in older adults.Journal of geriatric cardiology : JGC · 2016Article
- Respiratory Training Improves Blood Pressure Regulation in Individuals With Chronic Spinal Cord Injury.Archives of physical medicine and rehabilitation · 2016Article
- Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options.American journal of physiology. Heart and circulatory physiology · 2016Article
- Postural change in volunteers: sympathetic tone determines microvascular response to cardiac preload and output increases.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Patients with vasovagal syncope and neurogenic orthostatic hypotension can both present with pre-syncope and syncope resulting from systemic hypotension. While not directly responsible for increased mortality, both of these conditions can have a tremendous deleterious impact on the daily lives of patients. This negative impact can take the form of both physical symptoms and injury, but also a psychological impact from living in fear of the next syncopal episode. Despite these similarities, these are different disorders with fixed damage to the autonomic nerves in neurogenic orthostatic hypotension, as opposed to a transient reflex hypotension in "neurally mediated" vasovagal syncope. The treatment approaches for both disorders are parallel. The first step is to educate the patient about the pathophysiology and prognosis of their disorder. Next, offending medications should be withdrawn when possible. Non-pharmacological therapies and maneuvers can be used, both in an effort to prevent the symptoms and to prevent syncope at the onset of presyncope. This is all that is required in many patients with vasovagal syncope. If needed, pharmacological options are also available for both vasovagal syncope and neurogenic orthostatic hypotension, many of which are focused on blood volume expansion, increasing cardiac venous return, or pressor agents to increase vascular tone. There is a paucity of high-quality clinical trial data to support the use of these pharmacological agents. We aim to review the literature on these different therapy choices and to give recommendations on tailored approaches to the treatment of these conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.