ArticlePloS one2013
Two gastroenteritis outbreaks caused by GII Noroviruses: host susceptibility and HBGA phenotypes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Large-scale gastroenteritis outbreaks occurring in a university town of Guangzhou city during the global wave of the norovirus in China.Virology journal · 2026Article
- Norovirus replication, host interactions and vaccine advances.Nature reviews. Microbiology · 2025Review
- Secretor Status Strongly Influences the Incidence of Symptomatic Norovirus Infection in a Genotype-Dependent Manner in a Nicaraguan Birth Cohort.The Journal of infectious diseases · 2022Article
- Virus Etiology, Diversity and Clinical Characteristics in South African Children Hospitalised with Gastroenteritis.Viruses · 2021Article
- Article
- Virus-Host Interactions Between Nonsecretors and Human Norovirus.Cellular and molecular gastroenterology and hepatology · 2020Article
- Review
- Characterization of the new GII.17 norovirus variant that emerged recently as the predominant strain in China.The Journal of general virology · 2016Article
- Innate Resistance and Susceptibility to Norovirus Infection.PLoS pathogens · 2016Review
- Characterisation of a household norovirus outbreak occurred in Valencia (Spain).BMC infectious diseases · 2016Article
- An outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility.Scientific reports · 2015Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
- Article
- Norovirus.Clinical microbiology reviews · 2015Review
- Genetic susceptibility to norovirus GII.3 and GII.4 infections in Chinese pediatric diarrheal disease.The Pediatric infectious disease journal · 2014Article
- Association between norovirus and rotavirus infection and histo-blood group antigen types in Vietnamese children.Journal of clinical microbiology · 2014Article
- Treatment of norovirus infections: moving antivirals from the bench to the bedside.Antiviral research · 2014Review
- Epidemiology of human noroviruses and updates on vaccine development.Current opinion in gastroenterology · 2014Review
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Noroviruses (NoVs) cause epidemic acute gastroenteritis, in which histo-blood group antigens (HBGAs) may play an important role in the host susceptibility. To further explore this issue, two outbreaks of acute gastroenteritis caused by a GII.4 and a GII.3 NoV, respectively, in China in 2009 were studied. Stool and saliva samples from symptomatic patients and water samples from the outbreak facilities were collected. RT-PCR showed that 23 out of 33 (GII.4 outbreak) and 12 out of 13 (GII.3outbreak) stool samples were NoV positive. For the GII.4 outbreak the NoV sequences of stool and water samples were from an identical GII.4 strain, while the same GII.3 NoV sequences were found in five stool samples from the GII.3 outbreak. The HBGA phenotypes (A, B, Le(a), Le(b), Le(x), and Le(y)) of all saliva samples were determined, which revealed both secretors and nonsecretors in the symptomatic groups of the two outbreaks. In the GII.3 outbreak, type O individuals appeared less susceptible, while the type A may be more at risk of infection. However, No preference of HBGAs was observed in the GII.4 outbreak. The observation that nonsecretors were infected in both outbreaks differed from the previous results that nonsecretors are resistant to these two GII NoVs.
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