ArticlePloS one2013
Nanoscale examination of microdamage in sheep cortical bone using synchrotron radiation transmission x-ray microscopy.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- Advancements in High-Resolution Computed Tomography: Revolutionising Bone Health Micro-Research.Bioengineering (Basel, Switzerland) · 2025Article
- Microdamage in biological hard tissues and its repair mechanisms.Biomedical engineering online · 2025Review
- Assessment of subchondral bone microdamage quantification using contrast-enhanced imaging techniques.Journal of anatomy · 2024Article
- A Method for Evaluation the Fatigue Microcrack Propagation in Human Cortical Bone Using Differential X-ray Computed Tomography.Materials (Basel, Switzerland) · 2021Article
- Review
- Sub-trabecular strain evolution in human trabecular bone.Scientific reports · 2020Article
- Article
- Inter-site Variability of the Human Osteocyte Lacunar Network: Implications for Bone Quality.Current osteoporosis reports · 2019Review
- Article
- Bone quality changes associated with aging and disease: a review.Annals of the New York Academy of Sciences · 2017Review
- Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties.Scientific reports · 2017Article
- Bone quality assessment techniques: geometric, compositional, and mechanical characterization from macroscale to nanoscale.Clinical reviews in bone and mineral metabolism · 2016Article
- Article
- The Effect of Osteoporosis Treatments on Fatigue Properties of Cortical Bone Tissue.Bone reports · 2015Article
- Multiscale imaging of bone microdamage.Connective tissue research · 2015Review
- Microdamage caused by fatigue loading in human cancellous bone: relationship to reductions in bone biomechanical performance.PloS one · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Microdamage occurs in bone through repeated and excessive loading. Accumulation of microdamage weakens bone, leading to a loss of strength, stiffness and energy dissipation in the tissue. Imaging techniques used to examine microdamage have typically been limited to the microscale. In the current study microdamage was examined at the nanoscale using transmission x-ray microscopy with an x-ray negative stain, lead-uranyl acetate. Microdamage was generated in notched and unnotched beams of sheep cortical bone (2×2×20 mm), with monotonic and fatigue loading. Bulk sections were removed from beams and stained with lead-uranyl acetate to identify microdamage. Samples were sectioned to 50 microns and imaged using transmission x-ray microscopy producing projection images of microdamage with nanoscale resolution. Staining indicated microdamage occurred in both the tensile and compressive regions. A comparison between monotonic and fatigue loading indicated a statistically significant greater amount of stain present in fatigue loaded sections. Microdamage occurred in three forms: staining to existing bone structures, cross hatch damage and a single crack extending from the notch tip. Comparison to microcomputed tomography demonstrated differences in damage morphology and total damage between the microscale and nanoscale. This method has future applications for understanding the underlying mechanisms for microdamage formation as well as three-dimensional nanoscale examination of microdamage.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.