ArticlePloS one2013
Cortical plasticity induced by spike-triggered microstimulation in primate somatosensory cortex.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- A neuroprosthesis for restoring hand movement and sensation in a person with complete tetraplegia.Nature medicine · 2026Article
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Direct current stimulation modulates prefrontal cell activity and behaviour without inducing seizure-like firing.Brain : a journal of neurology · 2024Article
- Network structure mediates functional reorganization induced by optogenetic stimulation of non-human primate sensorimotor cortex.iScience · 2022Article
- Similarities Between Somatosensory Cortical Responses InducedFrontiers in neuroscience · 2022Article
- Article
- Engineered Axonal Tracts as "Living Electrodes" for Synaptic-Based Modulation of Neural Circuitry.Advanced functional materials · 2018Article
- Commentary: Injecting Instructions into Premotor Cortex.Frontiers in cellular neuroscience · 2018Article
- Optimization by Adaptive Stochastic Descent.PloS one · 2018Article
- Reward value is encoded in primary somatosensory cortex and can be decoded from neural activity during performance of a psychophysical task.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2016Article
- Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex.Neuroscience · 2016Article
- Restoring Behavior via Inverse Neurocontroller in a Lesioned Cortical Spiking Model Driving a Virtual Arm.Frontiers in neuroscience · 2016Article
- Erratum to: Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Article
- Article
- Multitarget Multiscale Simulation for Pharmacological Treatment of Dystonia in Motor Cortex.Frontiers in pharmacology · 2016Article
- Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Review
- Cortical magnification plus cortical plasticity equals vision?Vision research · 2015Review
- Cortical Spiking Network Interfaced with Virtual Musculoskeletal Arm and Robotic Arm.Frontiers in neurorobotics · 2015Article
- Gating of tactile information through gamma band during passive arm movement in awake primates.Frontiers in neural circuits · 2015Article
- Towards real-time communication betweenJournal of computational surgery · 2014Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical stimulation of the nervous system for therapeutic purposes, such as deep brain stimulation in the treatment of Parkinson's disease, has been used for decades. Recently, increased attention has focused on using microstimulation to restore functions as diverse as somatosensation and memory. However, how microstimulation changes the neural substrate is still not fully understood. Microstimulation may cause cortical changes that could either compete with or complement natural neural processes, and could result in neuroplastic changes rendering the region dysfunctional or even epileptic. As part of our efforts to produce neuroprosthetic devices and to further study the effects of microstimulation on the cortex, we stimulated and recorded from microelectrode arrays in the hand area of the primary somatosensory cortex (area 1) in two awake macaque monkeys. We applied a simple neuroprosthetic microstimulation protocol to a pair of electrodes in the area 1 array, using either random pulses or pulses time-locked to the recorded spiking activity of a reference neuron. This setup was replicated using a computer model of the thalamocortical system, which consisted of 1980 spiking neurons distributed among six cortical layers and two thalamic nuclei. Experimentally, we found that spike-triggered microstimulation induced cortical plasticity, as shown by increased unit-pair mutual information, while random microstimulation did not. In addition, there was an increased response to touch following spike-triggered microstimulation, along with decreased neural variability. The computer model successfully reproduced both qualitative and quantitative aspects of the experimental findings. The physiological findings of this study suggest that even simple microstimulation protocols can be used to increase somatosensory information flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.