Trial reportProceedings of the National Academy of Sciences of the United States of America2013
Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
279 citing papers in PubMed, 2 syntheses or guidelines pooled it, 565 citations in OpenAlex.
- Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- A systematic review of MEG-based studies in Parkinson's disease: The motor system and beyond.Human brain mapping · 2019Pooled it
- Boosting hemianopia recovery: the power of interareal cross-frequency brain stimulation.Brain : a journal of neurology · 2025Trial
- A randomized feasibility trial of medium chain triglyceride-supplemented ketogenic diet in people with Parkinson's disease.BMC neurology · 2024Trial
- Effects on resting-state EEG phase-amplitude coupling in insomnia disorder patients following 1 Hz left dorsolateral prefrontal cortex rTMS.Human brain mapping · 2023Trial
- Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation.Scientific reports · 2020Trial
- Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.Cell reports. Medicine · 2026Article
- Aberrant Gamma Oscillations in Parkinson's Disease.Neuroscience bulletin · 2026Review
- Mechanism and progress of deep brain stimulation in the treatment of neurological and psychiatric disorders.MedScience · 2026Review
- Low-intensity transcranial ultrasound stimulation suppresses abnormal neural oscillations in the motor cortex by stimulating STN in α-synucleinActa neuropathologica communications · 2026Article
- Cortico-pallidal beta dynamics underlie impaired turning in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Increased beta-HFO phase-amplitude coupling in the subthalamic nucleus during movement in Parkinson's disease.Neuroimage. Reports · 2026Article
- Electrocorticography During Deep Brain Stimulation Surgery for Movement Disorders: Single-Center Experience.Brain sciences · 2026Article
- Parkinsonism disrupts the population-level organization of cortical dynamics.bioRxiv : the preprint server for biology · 2026Article
- Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss.bioRxiv : the preprint server for biology · 2026Article
- Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state.Neuroimage. Reports · 2026Article
- Rapid Profiling of EEG Responses to Non-Invasive Brain Stimulation in Parkinson's Disease: A Biomarker-Driven Screening Framework.Biomedicines · 2026Article
- Multi-Channel Neural Interface for Neural Recording and Neuromodulation.Small methods · 2026Review
219 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
An important mechanism for large-scale interactions between cortical areas involves coupling between the phase and the amplitude of different brain rhythms. Could basal ganglia disease disrupt this mechanism? We answered this question by analysis of local field potentials recorded from the primary motor cortex (M1) arm area in patients undergoing neurosurgery. In Parkinson disease, coupling between β-phase (13-30 Hz) and γ-amplitude (50-200 Hz) in M1 is exaggerated compared with patients with craniocervical dystonia and humans without a movement disorder. Excessive coupling may be reduced by therapeutic subthalamic nucleus stimulation. Peaks in M1 γ-amplitude are coupled to, and precede, the subthalamic nucleus β-trough. The results prompt a model of the basal ganglia-cortical circuit in Parkinson disease incorporating phase-amplitude interactions and abnormal corticosubthalamic feedback and suggest that M1 local field potentials could be used as a control signal for automated programming of basal ganglia stimulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.