ReviewJournal of applied physiology (Bethesda, Md. : 1985)2014
Eccentric exercise in aging and diseased skeletal muscle: good or bad?
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Effects of exercise interventions on physical function, cognitive function and quality of life of frail older adults in nursing homes: a systematic review and meta-analysis.Frontiers in psychology · 2025Pooled it
- Effects of resistance training intensity on muscle quantity/quality in middle-aged and older people: a randomized controlled trial.Journal of cachexia, sarcopenia and muscle · 2022Trial
- Comparing high-intensity resistance training incorporating periodic eccentric-only exercise with blood flow restriction training in older men: physiological responses and exercise feasibility.European journal of applied physiology · 2026Article
- Age-related differences in muscular coordination while performing elbow flexion and extension movements at different velocities.Scientific reports · 2025Article
- Re‑examining the mechanism of eccentric exercise‑induced skeletal muscle damage from the role of the third filament, titin (Review).Biomedical reports · 2024Review
- Skeletal effects of eccentric strengthening exercise: a scoping review.BMC musculoskeletal disorders · 2023Article
- The chronic effects of eccentric exercise interventions in different populations: an umbrella review.European journal of translational myology · 2022Article
- Review
- Applications of Eccentric Exercise to Improve Muscle and Mobility Function in Older Adults.Annals of geriatric medicine and research · 2022Article
- Eccentric Exercise: Adaptations and Applications for Health and Performance.Journal of functional morphology and kinesiology · 2021Review
- Corticospinal excitability is altered similarly following concentric and eccentric maximal contractions.European journal of applied physiology · 2020Article
- Muscle Eccentric Contractions Increase in Downhill and High-Grade Uphill Walking.Frontiers in bioengineering and biotechnology · 2020Article
- Tendon Adaptations to Eccentric Exercise and the Implications for Older Adults.Journal of functional morphology and kinesiology · 2019Review
- Triceps Surae Muscle Architecture Adaptations to Eccentric Training.Frontiers in physiology · 2019Article
- Effectiveness of Grounded Sleeping on Recovery After Intensive Eccentric Muscle Loading.Frontiers in physiology · 2019Article
- Neuromuscular and Perceptual Responses to Sub-Maximal Eccentric Cycling.Frontiers in physiology · 2019Article
- Eccentric Muscle Contractions: Risks and Benefits.Frontiers in physiology · 2019Review
- Damaged muscle fibers might masquerade as hybrid fibers - a cautionary note on immunophenotyping mouse muscle with mouse monoclonal antibodies.European journal of histochemistry : EJH · 2018Article
- Non-invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography.Muscle & nerve · 2017Article
- Skeletal muscle water TNeuromuscular disorders : NMD · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Evidence is accumulating regarding the benefits of exercise in people who are more susceptible to injury, such as the elderly, or those with a neuromuscular disease, for example Duchenne muscular dystrophy (DMD). There appears to be a consensus that exercise can be safely performed in aging and diseased muscles, but the role of eccentric exercise is not as clear. Eccentric (lengthening) contractions have risks and benefits. Eccentric contractions are commonly performed on a daily basis, and high-force voluntary eccentric contractions are often employed in strength training paradigms with excellent results; however, high-force eccentric contractions are also linked to muscle damage. This minireview examines the benefits and safety issues of using eccentric exercise in at-risk populations. A common recommendation for all individuals is difficult to achieve, and guidelines are still being established. Some form of exercise is generally recommended with aging and even with diseased muscles, but the prescription (frequency, intensity, and duration) and type (resistance vs. aerobic) of exercise requires personal attention, as there is great diversity in the functional level and comorbidities in the elderly and those with neuromuscular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.