ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Two-layer model of coronary artery vasoactivity.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Myocardial infarction impaired wall mechanics and hemodynamics in peripheral arteries.Frontiers in physiology · 2023Article
- [Experimental measurement and modeling analysis of active and passive mechanical properties of arterial vessel wall].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Anisotropic residual stresses in arteries.Journal of the Royal Society, Interface · 2019Article
- Acute Tachycardia Increases Aortic Distensibility, but Reduces Total Arterial Compliance Up to a Moderate Heart Rate.Frontiers in physiology · 2018Article
- Passive and Active Triaxial Wall Mechanics in a Two-Layer Model of Porcine Coronary Artery.Scientific reports · 2017Article
- The Structure-function remodeling in rabbit hearts of myocardial infarction.Physiological reports · 2017Article
- Intraspecific scaling laws are preserved in ventricular hypertrophy but not in heart failure.American journal of physiology. Heart and circulatory physiology · 2016Article
- Microstructure-based biomechanics of coronary arteries in health and disease.Journal of biomechanics · 2016Review
- Remodeling of left circumflex coronary arterial tree in pacing-induced heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Biaxial deformation of collagen and elastin fibers in coronary adventitia.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Microstructural constitutive model of active coronary media.Biomaterials · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Since vascular tone is regulated by smooth muscle cells in the media layer, a multilayer mechanical model is required for blood vessels. Here, we performed biaxial mechanical tests in the intima-media layer of right coronary artery to determine the passive and active properties in conjunction with the passive properties of adventitia for a full vessel wall model. A two-layer (intima-media and adventitia) model was developed to determine the transmural stress and stretch across the vessel wall. The mean ± SE values of the outer diameters of intima-media layers at transmural pressure of 60 mmHg in active state were 3.17 ± 0.16 and 3.07 ± 0.18 mm at axial stretch ratio of 1.2 and 1.3, respectively, which were significantly smaller than those in passive state (i.e., 3.62 ± 0.19 and 3.49 ± 0.22 mm, respectively, P < 0.05). The inner and outer diameters in no-load state of intima-media layers were 1.17 ± 0.09 and 2.08 ± 0.09 mm, respectively. The opening angles in zero-stress state had values of 159 ± 21° for intima-media layers and 98 ± 15° for adventitia layers, which suggests a residual strain between the two layers. There were slightly decreased active circumferential stresses (<10%), but significantly decreased active axial stresses (>25%) in the intima-media layer compared with those in the intact vessel. This suggests that the adventitia layer affects vascular contraction. The two-layer analysis showed that the intima-media layer bears the majority of circumferential tensions, in contrast to the adventitia layer, while contraction results in decreased stress and stretch in both layers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.