ArticleGenes & nutrition2013
The genetics of childhood obesity and interaction with dietary macronutrients.
Article in Genes & nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global disparities in association between leisure-time physical activity and chronic musculoskeletal pain: A systematic review and meta-analysis.Global health research and policy · 2026Pooled it
- The association between breastfeeding and childhood obesity: a meta-analysis.BMC public health · 2014Pooled it
- Polygenic Childhood Obesity: Integrating Genetics and Environment for Early Intervention.Hormone research in paediatrics · 2026Review
- Mapping the Fat: How Childhood Obesity and Body Composition Shape Obstructive Sleep Apnoea.Children (Basel, Switzerland) · 2025Review
- Young-onset type 2 diabetes-Epidemiology, pathophysiology, and management.Journal of diabetes investigation · 2025Review
- Comprehending the Epidemiology and Aetiology of Childhood Obesity: Integrating Life Course Approaches for Prevention and Intervention.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Review
- MC4-R variant confirms its association with obesity during progression from childhood to adolescence.Scientific reports · 2025Article
- Mutational landscape of risk variants in comorbid depression and obesity: a next-generation sequencing approach.Molecular psychiatry · 2024Article
- Investigation of the interaction between genetic risk score (GRS) and fatty acid quality indices on metabolic syndrome among overweight and obese women.BMC medical genomics · 2024Article
- Article
- TT Genotype ofNutrients · 2023Article
- The Association between Breakfast Macronutrient Composition and Body Weight, in Preadolescence: An Epidemiological Study among Schoolchildren.Children (Basel, Switzerland) · 2022Article
- Healthy beverages may reduce the genetic risk of abdominal obesity and related metabolic comorbidities: a gene-diet interaction study in Iranian women.Diabetology & metabolic syndrome · 2022Article
- Leptin in Human Milk-One of the Key Regulators of Nutritional Programming.Molecules (Basel, Switzerland) · 2022Review
- Article
- Metabolomic Signatures for the Effects of Weight Loss Interventions on Severe Obesity in Children and Adolescents.Metabolites · 2021Article
- Maternal food restriction-induced intrauterine growth restriction in a rat model leads to sex-specific adipogenic programming.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The relationship between yogurt consumption, body weight, and metabolic profiles in youth with a familial predisposition to obesity.European journal of clinical nutrition · 2019Article
- The genetic and epigenetic association of LDL Receptor Related Protein 1B (LRP1B) gene with childhood obesity.Scientific reports · 2019Article
- CRISPR/Cas9, the Powerful New Genome-Editing Tool for Putative Therapeutics in Obesity.Journal of molecular neuroscience : MN · 2018Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The genes contributing to childhood obesity are categorized into three different types based on distinct genetic and phenotypic characteristics. These types of childhood obesity are represented by rare monogenic forms of syndromic or non-syndromic childhood obesity, and common polygenic childhood obesity. In some cases, genetic susceptibility to these forms of childhood obesity may result from different variations of the same gene. Although the prevalence for rare monogenic forms of childhood obesity has not increased in recent times, the prevalence of common childhood obesity has increased in the United States and developing countries throughout the world during the past few decades. A number of recent genome-wide association studies and mouse model studies have established the identification of susceptibility genes contributing to common childhood obesity. Accumulating evidence suggests that this type of childhood obesity represents a complex metabolic disease resulting from an interaction with environmental factors, including dietary macronutrients. The objective of this article is to provide a review on the origins, mechanisms, and health consequences of obesity susceptibility genes and interaction with dietary macronutrients that predispose to childhood obesity. It is proposed that increased knowledge of these obesity susceptibility genes and interaction with dietary macronutrients will provide valuable insight for individual, family, and community preventative lifestyle intervention, and eventually targeted nutritional and medicinal therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.