Trial reportEuropean journal of nuclear medicine and molecular imaging2013
The value of 18F-FDG PET/CT in diagnosing infectious endocarditis.
Trial report in European journal of nuclear medicine and molecular imaging, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Meta-analysis of 18F-FDG PET/CT in the diagnosis of infective endocarditis.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Pooled it
- Assessment of the diagnostic accuracy ofEuropean journal of nuclear medicine and molecular imaging · 2016Trial
- The role of 18F-FDG PET/CT in spinal infections: A comprehensive diagnostic tool.Brain & spine · 2026Article
- In Vivo Detection ofInternational journal of biomedical imaging · 2024Article
- The Role of Positron Emission Tomography in Advancing the Understanding of the Pathogenesis of Heart and Vascular Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- The role of [18F]FDG-PET/CT in gram-positive and gram-negative bacteraemia: A systematic review.Frontiers in nuclear medicine · 2022Review
- Surgical procedure versus medical treatment for infective endocarditis associated to mortality in Mexican population.Archivos de cardiologia de Mexico · 2021Article
- Infected peri-aortic hematoma diagnosed on F-18 FDG PET/CT imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Additive value of positron emission tomography/computed tomography scan for detection of aortic tube graft infection: a case report.European heart journal. Case reports · 2021Article
- State of the art ofClinical and translational imaging · 2021Review
- Multimodality Imaging in the Diagnostic Work-Up of Endocarditis and Cardiac Implantable Electronic Device (CIED) Infection.Journal of clinical medicine · 2020Review
- Usefulness ofEuropean heart journal. Case reports · 2019Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Review
- Advanced imaging improves the diagnosis of infective endocarditis.F1000Research · 2018Review
- A comparison of the diagnostic value of MRI andInfection · 2017Article
- Cross-sectional imaging of aortic infections.Insights into imaging · 2016Review
- Clinical Utility and Future Applications of PET/CT and PET/CMR in Cardiology.Diagnostics (Basel, Switzerland) · 2016Review
- FDG PET/CT in cardiac electronic devices infection: Now is the time to target guidelines implementation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Diagnosis of Bartonella henselae prosthetic valve endocarditis in man, France.Emerging infectious diseases · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEarly detection of infectious endocarditis is challenging. For diagnosing infectious endocarditis, the revised Duke criteria are the gold standard. Evidence of endocardial involvement on echocardiography is a major criterion, but sensitivity and specificity of echocardiography are not optimal. Here we investigated the utility of (18)F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) to diagnose infectious endocarditis in patients with gram-positive bacteraemia.
methodsSeventy-two patients with gram-positive bacteraemia were prospectively included. Patients with a positive blood culture growing Staphylococcus aureus, Streptococcus species or Enterococcus species were eligible when a risk factor for developing metastatic infectious foci was present. Infectious endocarditis was defined according to the revised Duke criteria. All patients underwent (18)F-FDG PET/CT and echocardiography. (18)F-FDG uptake in or around the heart valves was evaluated independently by two nuclear medicine physicians.
resultsSensitivity for diagnosing infectious endocarditis with (18)F-FDG PET/CT was 39% and specificity was 93%. The positive predictive value was 64% and negative predictive value was 82%. The mortality rate in patients without infectious endocarditis and without increased (18)F-FDG uptake in or around the heart valves was 18%, and in patients without infectious endocarditis but with high (18)F-FDG uptake in or around the heart valves the mortality rate was 50% (p = 0.181).
conclusion(18)F-FDG PET/CT is currently not sufficiently adequate for the diagnosis of infectious endocarditis because of its low sensitivity. Improvements such as patient preparation with low carbohydrate-fat allowed diet and technical advances in the newest PET/CT scanners may increase sensitivity in future studies.
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