ArticleJournal of materials science. Materials in medicine2013
Cross-linked hyaluronic acid sub-micron particles: in vitro and in vivo biodistribution study in cancer xenograft model.
Article in Journal of materials science. Materials in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
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- Quantification of Xanthone and Anthocyanin in Mangosteen Peel by UPLC-MS/MS and Preparation of Nanoemulsions for Studying Their Inhibition Effects on Liver Cancer Cells.International journal of molecular sciences · 2023Article
- Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived fromFoods (Basel, Switzerland) · 2023Article
- 3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity.Pharmaceutics · 2022Article
- Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells.Pharmaceutics · 2022Article
- VCAM-1 as a Biomarker of Endothelial Function among HIV-Infected Patients Receiving and Not Receiving Antiretroviral Therapy.Viruses · 2022Article
- Targeted Delivery of Chemotherapeutic Agents for Osteosarcoma Treatment.Frontiers in oncology · 2022Review
- A Glimpse of Inflammation and Anti-Inflammation Therapy in Diabetic Kidney Disease.Frontiers in physiology · 2022Review
- Systematic Patent Review of Nanoparticles in Drug Delivery and Cancer Therapy in the Last Decade.Recent advances in drug delivery and formulation · 2021Article
- Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells.Cell & bioscience · 2020Review
- Developing Body-Components-Based Theranostic Nanoparticles for Targeting Ovarian Cancer.Pharmaceutics · 2019Article
- Chitosan-coated liposomes loaded with butyric acid demonstrate anticancer and anti-inflammatory activity in human hepatoma HepG2 cells.Oncology reports · 2019Article
- Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs.Pharmaceutics · 2018Article
- Application of hyaluronic acid as carriers in drug delivery.Drug delivery · 2018Review
- Synthesis of functionalized Pluronic-b-poly(ε-caprolactone) and the comparative study of their pendant groups on the cellular internalization behavior.Journal of materials science. Materials in medicine · 2015Article
- A Lanthanum-Tagged Chemotherapeutic Agent HA-Pt to Track theBAOJ pharmaceutical sciences · 2015Article
- Ligand-based targeted therapy: a novel strategy for hepatocellular carcinoma.International journal of nanomedicineReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper focused on the biodistribution of the cross-linked hyaluronic acid (HA-NPs) sub-micron particles in tumor-bearing mice. Solvent-non solvent method followed glutaraldehyde cross-linking utilized for the fabrication of HA-NPs. Size measurement and morphological analysis were performed by dynamic light scattering and electron microscopy, respectively and the size found to be in the range of 200-400 nm. In vitro viability in LNCaP cell line was assessed by water soluble tetrazolium assay after 24 h of exposure to sub-micron particles and no toxicity was found to higher concentration of 3 mg/mL. Internalization of particles in prostate cancer cell LNCaP were studied by confocal microscopy with FITC labeled submicron particles and involvement of hyaluronan receptor mediated uptake/endocytosis was confirmed by competitive assay. Biodistribution studies were performed in xenograft prostate cancer mice model with fluorophore labeled particles and monitored in tumoral parenchyma with strong fluorescence, meanwhile very less signal in liver, kidney and spleen while no fluorescence found in lung after 24 h of systemic administration; that shown ability of this HA based system to recognize cancer tissue. These result fetched that hyaluronic acid based system is selective for tumoral site and can be utilized to deliver bioactives in specific (targeting) and controlled (temporal) manner to cancerous tissue.
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Registered trials
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