ArticleTheranostics2013
Phase and size controllable synthesis of NaYbF4 nanocrystals in oleic acid/ionic liquid two-phase system for targeted fluorescent imaging of gastric cancer.
Article in Theranostics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Surface bioengineering of lanthanide nanoparticles for theranostic applications: From hydrophilic modification to multimodal imaging and therapy.Materials today. Bio · 2026Review
- A NIR-IIb-excited capsule endoscope enabling high-contrast fluorescence imaging via spectrally-isolated detection for early-stage gastrointestinal cancer.Journal of nanobiotechnology · 2026Article
- Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19.Frontiers in bioengineering and biotechnology · 2023Article
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- Nanotechnology-Assisted Cell Tracking.Nanomaterials (Basel, Switzerland) · 2022Review
- Lanthanide-Doped Luminescent NanophosphorsFrontiers in chemistry · 2021Review
- Application of a double-colour upconversion nanofluorescent probe for targeted imaging of mantle cell lymphoma.Oncotarget · 2018Article
- Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells.OncoTargets and therapy · 2018Article
- Article
- Enhanced UV upconversion emission using plasmonic nanocavities.Optics express · 2016Article
- Reduced expression of the long non-coding RNA AI364715 in gastric cancer and its clinical significance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Hexamodal imaging with porphyrin-phospholipid-coated upconversion nanoparticles.Advanced materials (Deerfield Beach, Fla.) · 2015Article
- MALDI-TOF Mass Array Analysis of Nell-1 Promoter Methylation Patterns in Human Gastric Cancer.BioMed research international · 2015Article
- Size-tunable and monodisperse Tm³⁺/Gd³⁺-doped hexagonal NaYbF₄ nanoparticles with engineered efficient near infrared-to-near infrared upconversion for in vivo imaging.ACS applied materials & interfaces · 2014Article
- RGD-conjugated silica-coated gold nanorods on the surface of carbon nanotubes for targeted photoacoustic imaging of gastric cancer.Nanoscale research letters · 2014Article
- Shape-controllable synthesis of hydrophilic NaLuF4:Yb,Er nanocrystals by a surfactant-assistant two-phase system.Nanoscale research letters · 2013Article
- Decreased expression of long noncoding RNA AC096655.1-002 in gastric cancer and its clinical significance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Folic acid-conjugated silica capped gold nanoclusters for targeted fluorescence/X-ray computed tomography imaging.Journal of nanobiotechnology · 2013Article
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8 authors.
Funding
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Abstract
Upconversion nanocrystals with small size and strong fluorescent signals own great potential in applications such as biomolecule-labeling, in vivo tracking and molecular imaging. Herein we reported that NaYbF4: 25%Gd, 2%Tm upconversion nanocrystals with small size and strong fluorescent signals were controllably synthesized by oleic acid (OA)/ ionic liquid (IL) two-phase system for targeted fluorescent imaging of gastric cancer in vivo. The optimal synthesis condition of NaYbF4: 25%Gd, 2%Tm upconversion nanocrystals by OA/IL two-phase system was established, adding more metal ion such as Na(+) ion could facilitate the size control and crystal-phase transition, more importantly, markedly enhancing fluorescent intensity of beta-phase nanocrystals compared with traditional methods. Alpha-phase NaYbF4, 2%Tm upconversion nanocrystals with less than 10nm in diameter and beta-phase NaYbF4: 25%Gd, 2%Tm upconversion nanocrystals with 30 nm or so in diameter and strong fluorescent signals were obtained, these synthesized nanocrystals exhibited very low cytotoxicity. Folic acid-conjugated silica-modified beta-phase NaYbF4: 25%Gd, 2%Tm upconversion nanocrystals were prepared, could actively target gastric cancer tissues implanted into nude mice in vivo, and realized targeted fluorescent imaging. Folic acid-conjugated silica-modified NaYbF4: 25%Gd, 2%Tm upconversion nanocrystals show great potential in applications such as targeted near infared radiation fluorescent imaging, magnetic resonance imaging and targeted therapy of gastric cancer in the near future.
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