Trial reportJAMA internal medicine2013
Centralized, stepped, patient preference-based treatment for patients with post-acute coronary syndrome depression: CODIACS vanguard randomized controlled trial.
Trial report in JAMA internal medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01032018 (Comparison of Depression Interventions After Acute Coronary Syndrome), which is not on this map. Cited by 76 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Depression Interventions After Acute Coronary Syndrome (CODIACS)
Who cites it
76 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Psychological eHealth Interventions for Patients With Cardiovascular Diseases: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Specific content for collaborative care: a systematic review of collaborative care interventions for patients with multimorbidity involving depression and/or anxiety in primary care.Family practice · 2022Pooled it
- Pooled it
- Psychological and pharmacological interventions for depression in patients with coronary artery disease.The Cochrane database of systematic reviews · 2021Pooled it
- Interventions to Increase Depression Treatment Initiation in Primary Care Patients: a Systematic Review.Journal of general internal medicine · 2018Pooled it
- Psychological interventions for coronary heart disease.The Cochrane database of systematic reviews · 2017Pooled it
- Pooled it
- The contribution of major depression to the global burden of ischemic heart disease: a comparative risk assessment.BMC medicine · 2013Pooled it
- Pooled it
- Longer-term effects of modernized collaborative care for depression on multiple mental health factors (eIMPACT): A randomized controlled trial.Journal of affective disorders · 2026Trial
- Feasibility of a web video-based positive word stimulation program for older patients with cardiac disease and subthreshold depression admitted to an acute care ward: a pilot randomized controlled trial.European geriatric medicine · 2025Trial
- Effect of modernized collaborative care for depression on brain-derived neurotrophic factor (BDNF) and depressive symptom clusters: Data from the eIMPACT trial.Psychiatry research · 2023Trial
- Effect of modernized collaborative care for depression on depressive symptoms and cardiovascular disease risk biomarkers: eIMPACT randomized controlled trial.Brain, behavior, and immunity · 2023Trial
- Longer term benefits of exercise and escitalopram in the treatment of anxiety in patients with coronary heart disease: Six month follow-up of the UNWIND randomized clinical trial.American heart journal · 2022Trial
- Trial
- Effect of Depression Screening After Acute Coronary Syndromes on Quality of Life: The CODIACS-QoL Randomized Clinical Trial.JAMA internal medicine · 2020Trial
- Collaborative care for depression symptoms in an outpatient cardiology setting: A randomized clinical trial.International journal of cardiology · 2016Trial
- Trial
- Effect of collaborative care for depression on risk of cardiovascular events: data from the IMPACT randomized controlled trial.Psychosomatic medicine · 2014Trial
- Economic outcomes of depression screening after acute coronary syndromes: The CODIACS-QoL randomized clinical trial.General hospital psychiatryTrial
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
importanceControversy remains about whether depression can be successfully managed after acute coronary syndrome (ACS) and the costs and benefits of doing so.
objectiveTo determine the effects of providing post-ACS depression care on depressive symptoms and health care costs.
designMulticenter randomized controlled trial.
settingPatients were recruited from 2 private and 5 academic ambulatory centers across the United States.
participantsA total of 150 patients with elevated depressive symptoms (Beck Depression Inventory [BDI] score ≥10) 2 to 6 months after an ACS, recruited between March 18, 2010, and January 9, 2012.
interventionsPatients were randomized to 6 months of centralized depression care (patient preference for problem-solving treatment given via telephone or the Internet, pharmacotherapy, both, or neither), stepped every 6 to 8 weeks (active treatment group; n = 73), or to locally determined depression care after physician notification about the patient's depressive symptoms (usual care group; n = 77).
main outcome measuresChange in depressive symptoms during 6 months and total health care costs.
resultsDepressive symptoms decreased significantly more in the active treatment group than in the usual care group (differential change between groups, -3.5 BDI points; 95% CI, -6.1 to -0.7; P = .01). Although mental health care estimated costs were higher for active treatment than for usual care, overall health care estimated costs were not significantly different (difference adjusting for confounding, -$325; 95% CI, -$2639 to $1989; P = .78).
conclusionsFor patients with post-ACS depression, active treatment had a substantial beneficial effect on depressive symptoms. This kind of depression care is feasible, effective, and may be cost-neutral within 6 months; therefore, it should be tested in a large phase 3 pragmatic trial.
trial registrationclinicaltrials.gov Identifier: NCT01032018.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.