ReviewAdvances in physiology education2013
The force-frequency relationship: insights from mathematical modeling.
Review in Advances in physiology education, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Temperature alters the inotropic and chronotropic effect of DNaunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Mechano-energetic uncoupling in heart failure.Nature reviews. Cardiology · 2025Review
- A new method to evaluate staircase phenomenon in skeletal muscle using piezoelectric sensor.Clinical neurophysiology practice · 2025Article
- The Role of CaBiomolecules · 2022Article
- Intra-subject stability of different expressions of spatial QRS-T angle and their relationship to heart rate.Frontiers in physiology · 2022Article
- Myocardial Contractility: Historical and Contemporary Considerations.Frontiers in physiology · 2020Article
- Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System.Frontiers in physiology · 2019Article
- Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues.Nature communications · 2017Article
- A role for membrane shape and information processing in cardiac physiology.Pflugers Archiv : European journal of physiology · 2015Review
- Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions.Pflugers Archiv : European journal of physiology · 2014Review
- In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling.Frontiers in physiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The force-frequency relationship has intrigued researchers since its discovery by Bowditch in 1871. Many attempts have been made to construct mathematical descriptions of this phenomenon, beginning with the simple formulation of Koch-Wesser and Blinks in 1963 to the most sophisticated ones of today. This property of cardiac muscle is amplified by β-adrenergic stimulation, and, in a coordinated way, the neurohumoral state alters both frequency (acting on the sinoatrial node) as well as force generation (modifying ventricular myocytes). This synchronized tuning is needed to meet new metabolic demands. Cardiac modelers have already linked mechanical and electrical activity in their formulations and showed how those activities feedback on each other. However, now it is necessary to include neurological control to have a complete description of heart performance, especially when changes in frequency are involved. Study of arrhythmias (or antiarrhythmic drugs) based on mathematical models should incorporate this effect to make useful predictions or point out potential pharmaceutical targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.