ArticleChest2013
Altered circadian rhythmicity in patients in the ICU.
Article in Chest, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Stress and circulating cell-free mitochondrial DNA: A systematic review of human studies, physiological considerations, and technical recommendations.Mitochondrion · 2021Pooled it
- Trial
- The Effects of Timed Light Exposure in Critically Ill Patients: A Randomized Controlled Pilot Clinical Trial.American journal of respiratory and critical care medicine · 2018Trial
- Quantifying sleep wake rhythms in the hospital environment with digital technologies.NPJ digital medicine · 2026Article
- Optimizing Sleep Hygiene in the Hospital Environment.Sleep medicine clinics · 2025Review
- Quantifying Sleep-Wake Rhythms in the Hospital Environment with Digital Technologies.medRxiv : the preprint server for health sciences · 2025Article
- Distinct diurnal temperature rhythm patterns in critical illness myopathy: secondary analysis of two prospective trials.Annals of intensive care · 2025Article
- Article
- Chrononutrition in Critical Illness.Nutrition reviews · 2025Review
- It's All About the CREY!Function (Oxford, England) · 2024Article
- Using routinely collected clinical data for circadian medicine: A review of opportunities and challenges.PLOS digital health · 2024Review
- Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury.Experimental neurology · 2024Article
- Disruption of the circadian rhythm of melatonin: A biomarker of critical illness severity.Sleep medicine · 2023Article
- Changes in Body Temperature Patterns Are Predictive of Mortality in Septic Shock: An Observational Study.Biology · 2023Article
- Causes, Consequences, and Treatments of Sleep and Circadian Disruption in the ICU: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- Adding Insult to Injury: Sleep Deficiency in Hospitalized Patients.Clinics in chest medicine · 2022Review
- Anterior Pituitary Hormones in Blood and Cerebrospinal Fluid of Patients in Neurocritical Care.TouchREVIEWS in endocrinology · 2022Article
- Association between circadian variation of heart rate and mortality among critically ill patients: a retrospective cohort study.BMC anesthesiology · 2022Observational
- Sleep Assessment in Critically Ill Adults: Established Methods and Emerging Strategies.Critical care explorations · 2022Review
- Multi-tissue transcriptional changes and core circadian clock disruption following intensive care.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPatients in the ICU are thought to have abnormal circadian rhythms, but quantitative data are lacking.
methodsTo investigate circadian rhythms in the ICU, we studied core body temperatures over a 48-h period in 21 patients (59 ± 11 years of age; eight men and 13 women).
resultsThe circadian phase position for 17 of the 21 patients fell outside the published range associated with morningness/eveningness, which determines the normative range for variability among healthy normal subjects. In 10 patients, the circadian phase position fell earlier than the normative range; in seven patients, the circadian phase position fell later than the normative range. The mean ± SD of circadian displacement in either direction (advance or delay) was 4.44 ± 3.54 h. There was no significant day-to-day variation of the 24-h temperature profile within each patient. Stepwise linear regression was performed to determine if age, sex, APACHE (Acute Physiology and Chronic Health Evaluation) III score, or day in the ICU could predict the patient-specific magnitude of circadian displacement. The APACHE III score was found to be significantly predictive of circadian displacement.
conclusionsThe findings indicate that circadian rhythms are present but altered in patients in the ICU, with the degree of circadian abnormality correlating with severity of illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.