Evidence map›Paper›PMID 23471081›Full record

ArticleInternational journal of medical sciences2013

Curcumin attenuates diabetic neuropathic pain by downregulating TNF-α in a rat model.

Yue Li, Yong Zhang, De-bao Liu, Hai-ying Liu, Wu-gang Hou, Yu-shu Dong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Article
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  9. Review
  10. The Gut Microbiota and Chronic Pain.Current pain and headache reports · 2024
    Review
  11. Review
  12. Effect of curcumin on formalin-induced muscle pain in male rats: role of local cyclooxygenase system.Veterinary research forum : an international quarterly journal · 2024
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
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  20. Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yue LiDepartment of air logistics, the 463 Hospital of PLA, Shenyang 110042, PR China.
Yong Zhang
De-bao Liu
Hai-ying Liu
Wu-gang Hou
Yu-shu Dong
Army Sustainment University · USShenyang 242 Hospital · CNJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms involved in diabetic neuropathic pain are complex and involve peripheral and central pathophysiological phenomena. Proinflammatory tumour necrosis factor α (TNF-α) and TNF-α receptor 1, which are markers of inflammation, contribute to neuropathic pain. The purpose of this experimental study was to evaluate the effect of curcumin on diabetic pain in rats. We tested 24 rats with diabetes induced by a single intraperitoneal injection of streptozotocin and 24 healthy control rats. Twelve rats in each group received 60 mg/kg oral curcumin daily for 28 days, and the other 12 received vehicle. On days 7, 14, 21, and 28, we tested mechanical allodynia with von Frey hairs and thermal hyperalgesia with radiant heat. Markers of inflammation in the spinal cord dorsal horn on day 28 were estimated with a commercial assay and Western blot analysis. Compared to control rats, diabetic rats exhibited increased mean plasma glucose concentration, decreased mean body weight, and significant pain hypersensitivity, as evidenced by decreased paw withdrawal threshold to von Frey hairs and decreased paw withdrawal latency to heat. Curcumin significantly attenuated the diabetes-induced allodynia and hyperalgesia and reduced the expression of both TNF-α and TNF-α receptor 1. Curcumin seems to relieve diabetic hyperalgesia, possibly through an inhibitory action on TNF-α and TNF-α receptor 1.

Indexed as

AnimalsBlood GlucoseCurcuminDiabetes Mellitus, ExperimentalDiabetic NeuropathiesDisease Models, AnimalDown-RegulationGene Expression RegulationHumansHyperalgesiaMaleNeuralgiaRatsTumor Necrosis Factor-alphaBlood GlucoseCurcuminTumor Necrosis Factor-alphacurcumindiabetic neuropathic painhyperalgesiatumour necrosis factor αtumour necrosis factor α receptor 1.

Identifiers

PMID23471081
PMCPMC3590595
OpenAlexW2156604564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.