ArticleInternational journal of medical sciences2013
Novel powdered anti-adhesion material: preventing postoperative intra-abdominal adhesions in a rat model.
Article in International journal of medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 37 citations in OpenAlex.
- Multimodal Evaluation of the Anti-Adhesion Effects of Heparin-Loaded PLGA/HA Nanofiber Membranes in an Intraperitoneal Adhesion Model in Rats.International journal of molecular sciences · 2026Article
- Biomaterials in pancreatic surgery: progress and challenges in preoperative, intraoperative and postoperative care.Theranostics · 2026Review
- The Therapeutic Potential of Targeting Key Signaling Pathways as a Novel Approach to Ameliorating Post-Surgical Adhesions.Current pharmaceutical design · 2022Review
- A novel coenzyme-Q approach for the prevention of postsurgical adhesion.Turkish journal of surgery · 2020Article
- Evaluation of the effects of adipose-derived mesenchymal stem cells on intraperitoneal adhesions.Turkish journal of surgery · 2018Article
- A new bioabsorbable polymer film to prevent peritoneal adhesions validated in a post-surgical animal model.PloS one · 2018Article
- Anti-adhesive effects of a newly developed two-layered gelatin sheet in dogs.The journal of obstetrics and gynaecology research · 2017Article
- Evaluation of botulinum toxin type A effectiveness in preventing postoperative intraperitoneal adhesions.Annals of surgical treatment and research · 2017Article
- Peritoneal response to abdominal surgery: the role of equine abdominal adhesions and current prophylactic strategies.Veterinary medicine international · 2014Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough laparoscopic surgery has decreased postoperative adhesions, complications induced by adhesions are still of great concern. The aim of this study was to investigate the anti-adhesive effects of a novel powdered anti-adhesion material that can be applied during laparoscopic surgery in comparison with other anti-adhesion materials.
methodsOur novel powdered anti-adhesion material is composed of aldehyde dextran and ε-poly(L-lysine). In 40 male rats, a 2.5×2.0-cm abdominal wall resection and cecum abrasion were performed. The rats were randomized into four groups based on the anti-adhesion treatments: normal saline; Seprafilm(®); Interceed(®); and novel powdered anti-adhesion material. The animals were euthanized on days 7 and 28 to evaluate the adhesion severity, area of adhesion formation, gross appearance, and pathological changes.
resultsThe adhesion severities on both days 7 and 28 were significantly lower for all anti-adhesion material groups compared with the normal saline group (p<0.05). Pathologically, all groups showed inflammatory cell infiltration on day 7 and complete regeneration of the peritoneum on day 28.
conclusionsOur novel powdered anti-adhesion material was found to be effective for reducing postoperative intra-abdominal adhesions and showed equivalent efficacy to commercial anti-adhesion materials.
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