ArticleThe Journal of infectious diseases2013
Spontaneous resolution of genital Chlamydia trachomatis infection in women and protection from reinfection.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Who Is Best to Test? A Systematic Review of Chlamydia Infections in Switzerland.International journal of environmental research and public health · 2020Pooled it
- An agent-based platform for simulating the impact of chlamydia vaccine in the US population.Nature communications · 2026Article
- The Impact of Chlamydia Treatment During Pregnancy on Birth Defects in New York State.Birth defects research · 2026Article
- Vaccination as a strategy for Chlamydia trachomatis control: a global mathematical modeling analysis.BMC global and public health · 2025Article
- Neutralizing Antibody Responses to Chlamydia trachomatis in Women and Associations With Chlamydia Outcomes.The Journal of infectious diseases · 2025Article
- Cross-sectional study on the seroprevalence, reinfection, and associated factors of Chlamydia trachomatis among female sex workers in Guangdong Province, China.BMC infectious diseases · 2025Article
- T cell signatures associated with reduced Chlamydia trachomatis reinfection in a highly exposed cohort.JCI insight · 2025Article
- Prevalence and risk factors for Chlamydia trachomatis seropositivity and seropersistence among women: A prospective cohort study.PloS one · 2025Article
- Genome-wide association study of chlamydia reinfection in African American women.Frontiers in immunology · 2025Article
- Interferon-γ Responses to Chlamydia trachomatis Vaccine Candidate Proteins in Women With Different Chlamydia Outcomes.The Journal of infectious diseases · 2024Article
- Immunity to Sexually Transmitted Bacterial Infections of the Female Genital Tract: Toward Effective Vaccines.Vaccines · 2024Review
- Impact of a potential Chlamydia vaccine in the USA: mathematical modelling analyses.BMJ public health · 2024Article
- Advances in vaccine development for Chlamydia trachomatis.Pathogens and disease · 2024Review
- Lower Urinary Tract Inflammation and Infection: Key Microbiological and Immunological Aspects.Journal of clinical medicine · 2024Review
- Review
- Antibody responses toFrontiers in cellular and infection microbiology · 2024Article
- Using infection prevalence, seroprevalence and case report data to estimate chlamydial infection incidence.Sexually transmitted infections · 2023Article
- What's on the rise in Sexually Transmitted Infections?The Lancet regional health. Europe · 2023Article
- Bacterial Vaginosis and Spontaneous Clearance of Chlamydia trachomatis in the Longitudinal Study of Vaginal Flora.The Journal of infectious diseases · 2023Article
- Important considerations regarding the widespread use of doxycycline chemoprophylaxis against sexually transmitted infections.The Journal of antimicrobial chemotherapy · 2023Review
20 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
Abstract
The natural history of chlamydia is variable and may include persisting asymptomatic infection, complications, or spontaneous resolution before treatment. Reinfection is common. We evaluated whether spontaneous resolution was associated with decreased reinfection in women returning for treatment of a positive chlamydia screening test. At enrollment, participants were tested for chlamydia, treated with azithromycin, and scheduled for a 6-month follow-up visit for repeat testing. Two hundred participants returned 1 to 12 months after treatment. Spontaneous resolution at enrollment was demonstrated in 44 (22.0%). Reinfection at follow-up occurred in 33 (16.5%), being more frequent in those with persisting infection at enrollment versus spontaneous resolution (31 of 156 [19.9%] vs 2 of 44 [4.5%]; P = .016). Adjusting for age, the odds of reinfection was 4 times higher for participants with persisting infection at enrollment (odds ratio 4.0, 95% confidence interval, 1.1-25.6; P = .034). Chlamydia treatment may attenuate protective immunity in some patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.