ReviewCurrent opinion in nephrology and hypertension2013
Rethinking hypertensive kidney disease: arterionephrosclerosis as a genetic, metabolic, and inflammatory disorder.
Review in Current opinion in nephrology and hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Chronic kidney disease among patients with hypertension in sub-Saharan Africa: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Associations of Nephron Number, Birth Weight, and Causes of Death in a Community at High Risk of Hypertension and Cardiovascular Disease.Kidney medicine · 2026Article
- Hypertension and age-related focal global glomerulosclerosis are associated with biomarkers for cellular senescence.Physiological reports · 2026Article
- Histopathological evaluation in post-mortem renal biopsies of patients with COVID-19 and comorbidities: a case-control study.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Causal role of the plasma lipidome in the occurrence and progression of chronic kidney disease: a two-sample Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- Advances in kidney disease: pathogenesis and therapeutic targets.Frontiers in medicine · 2025Review
- Heterogeneous afferent arteriolopathy: a key concept for understanding blood pressure-dependent renal damage.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- The renal histopathology of nonproteinuric kidney impairment: a three center experience.Clinical and experimental medicine · 2024Article
- Global, regional, and national burden inequality of chronic kidney disease, 1990-2021: a systematic analysis for the global burden of disease study 2021.Frontiers in medicine · 2024Article
- Associations between APOL1 genetic variants and blood pressure in African American mothers and children from a U.S. pregnancy cohort: Modification by air pollution exposures.Environmental research · 2022Article
- APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort Study.American journal of nephrology · 2022Article
- Article
- Kidney disease and APOL1.Human molecular genetics · 2021Review
- Genetic susceptibility of hypertension-induced kidney disease.Physiological reports · 2021Review
- Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury.American journal of physiology. Renal physiology · 2020Article
- Current findings of kidney biopsy including nephropathy associated with hypertension and diabetes mellitus in Korea.The Korean journal of internal medicine · 2020Article
- A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure.Kidney international · 2020Article
- Clinical Phenotypes and Long-term Prognosis in White Patients With Biopsy-Verified Hypertensive Nephrosclerosis.Kidney international reports · 2020Article
- Novel histopathologic predictors for renal outcomes in crescentic glomerulonephritis.PloS one · 2020Article
- Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type 2 diabetes patients with diabetic nephropathy.Journal of diabetes investigation · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewHypertension is the attributed cause of approximately 30% of end-stage kidney disease cases in the United States, but there has been controversy as to whether benign hypertension is a cause of chronic kidney disease. RECENT
findingsThe histology of chronic kidney disease attributed to nonmalignant hypertension is arterionephrosclerosis, with pathology in the terminal branches of the interlobular arteries, together with global glomerulosclerosis. The identification of coding region variants in APOL1, encoding apolipoprotein L1, has opened a new perspective on this debate. These variants are restricted to populations of recent African descent and are strongly associated with clinically diagnosed arterionephrosclerosis, particularly when there is moderate-grade or high-grade proteinuria or progression to more advanced levels of kidney dysfunction. Nevertheless, not all African Americans with hypertension who progress to end-stage kidney disease have two APOL1 risk variants, and individuals of European and Asian descent also manifest arterionephrosclerosis. Further, we do not understand the mechanisms by which APOL1 initiates pathology in the renal microcirculation. SUMMARY: APOL1 nephropathy comprises a disease spectrum (perhaps with distinct endophenotypes), including focal segmental glomerulosclerosis, collapsing glomerulopathy, and arterionephrosclerosis. The terms hypertensive kidney disease and hypertensive nephrosclerosis have outlived their usefulness. It may be time to use the established, etiologically neutral term, arterionephrosclerosis, to consider whether this is a disease rather than a pathologic description, and to determine the causal role of various clinical correlates including aging, obesity, hyperlipidemia, smoking, chronic inflammation, and oxidative stress.
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