SynthesisJournal of hypertension2013
Genetic and environmental influences on blood pressure variability: a study in twins.
Synthesis in Journal of hypertension, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Specific genetic influences on nighttime blood pressure.American journal of hypertension · 2015Pooled it
- Ambulatory Blood Pressure Monitoring in Children: A Cross-Sectional Study of Blood Pressure Indices.Children (Basel, Switzerland) · 2025Article
- Cardiovascular variability, sociodemographics, and biomarkers of disease: the MIDUS study.Frontiers in physiology · 2023Article
- Visit-to-visit blood pressure variability and mortality and cardiovascular outcomes after acute myocardial infarction.Journal of human hypertension · 2022Article
- The genetic architecture of blood pressure variability: A genome-wide association study of 9370 participants from UK Biobank.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- High Blood Pressure in Children and Adolescents: Current Perspectives and Strategies to Improve Future Kidney and Cardiovascular Health.Kidney international reports · 2022Review
- Chiropractic care for hypertension: Review of the literature and study of biological and genetic bases.Acta bio-medica : Atenei Parmensis · 2020Review
- Association Between Visit-to-Visit Blood Pressure Variability in Early Adulthood and Myocardial Structure and Function in Later Life.JAMA cardiology · 2020Article
- Genetic and Environmental Effects on Gene Expression Signatures of Blood Pressure: A Transcriptome-Wide Twin Study.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Maternal undernutrition and excessive body weight and risk of birth and health outcomes.Archives of public health = Archives belges de sante publique · 2017Article
- Body Size Predicts Cardiac and Vascular Resistance Effects on Men's and Women's Blood Pressure.Frontiers in physiology · 2017Article
- Relationship of adiposity and cardiorespiratory fitness with resting blood pressure of South African adolescents: the PAHL Study.Journal of human hypertension · 2016Article
- Article
- Arterial pressure and cerebral blood flow variability: friend or foe? A review.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivesBlood pressure variability (BPV) and its reduction in response to antihypertensive treatment are predictors of clinical outcomes; however, little is known about its heritability. In this study, we examined the relative influence of genetic and environmental sources of variance of BPV and the extent to which it may depend on race or sex in young twins.
methodsTwins were enrolled from two studies. One study included 703 white twins (308 pairs and 87 singletons) aged 18-34 years, whereas another study included 242 white twins (108 pairs and 26 singletons) and 188 black twins (79 pairs and 30 singletons) aged 12-30 years. BPV was calculated from 24-h ambulatory blood pressure recording.
resultsTwin modeling showed similar results in the separate analysis in both twin studies and in the meta-analysis. Familial aggregation was identified for SBP variability (SBPV) and DBP variability (DBPV) with genetic factors and common environmental factors together accounting for 18-40% and 23-31% of the total variance of SBPV and DBPV, respectively. Unique environmental factors were the largest contributor explaining up to 82-77% of the total variance of SBPV and DBPV. No sex or race difference in BPV variance components was observed. The results remained the same after adjustment for 24-h blood pressure levels.
conclusionsThe variance in BPV is predominantly determined by unique environment in youth and young adults, although familial aggregation due to additive genetic and/or common environment influences was also identified explaining about 25% of the variance in BPV.
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