ArticleCancer informatics2013
In silico discovery of mitosis regulation networks associated with early distant metastases in estrogen receptor positive breast cancers.
Article in Cancer informatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- MiR-193b as an effective biomarker in human cancer prognosis for Asian patients: a meta-analysis.Translational cancer research · 2022Article
- NF-YA Overexpression in Lung Cancer: LUAD.Genes · 2020Article
- NF-YA Overexpression in Lung Cancer: LUSC.Genes · 2019Article
- Overexpression and alternative splicing of NF-YA in breast cancer.Scientific reports · 2019Article
- LIFR-AS1 modulates Sufu to inhibit cell proliferation and migration by miR-197-3p in breast cancer.Bioscience reports · 2019Article
- Computational identification of tissue-specific transcription factor cooperation in ten cattle tissues.PloS one · 2019Article
- G-DOC Plus - an integrative bioinformatics platform for precision medicine.BMC bioinformatics · 2016Article
- ERRγ target genes are poor prognostic factors in Tamoxifen-treated breast cancer.Journal of experimental & clinical cancer research : CR · 2015Article
- Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.Journal of Cancer · 2015Review
- Incorporating prior knowledge into Gene Network Study.Bioinformatics (Oxford, England) · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The aim of this study was to perform comparative analysis of multiple public datasets of gene expression in order to identify common genes as potential prognostic biomarkers. Additionally, the study sought to identify biological processes and pathways that are most significantly associated with early distant metastases (<5 years) in women with estrogen receptor-positive (ER+) breast tumors. Datasets from three published studies were selected for in silico analysis of gene expression profiles of ER+ breast cancer, using time to distant metastasis as the clinical endpoint. A subset of 44 differently expressed genes (DEGs) was found common to all three studies and characterized by mitotic checkpoint genes and pathways that regulate mitotic spindle and chromosome dynamics. DEG promoter regions were enriched with NFY binding sites. Analysis of miRNA target sites identified significant enrichment of miR-192, miR-193B, and miR-16-1 targets. Aberrant mitotic regulation could drive increased genomic instability leading to a progression towards an early onset metastatic phenotype. The relative importance of mitotic instability may reflect the clinical utility of mitotic poisons in metastatic breast cancer, including poisons such as the taxanes, epothilones, and vinca alkaloids.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.