ArticleAmerican journal of respiratory cell and molecular biology2013
Short palate, lung, and nasal epithelial clone-1 is a tightly regulated airway sensor in innate and adaptive immunity.
Article in American journal of respiratory cell and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Impaired CC16-mediated host responses to rhinovirus in nasal epithelial cells from patients with asthma.The Journal of allergy and clinical immunology · 2026Article
- CC16 drives VLA-2-dependent SPLUNC1 expression.Frontiers in immunology · 2023Article
- SPLUNC1 is a negative regulator of the Orai1 CaPhysiological reports · 2022Article
- Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.American journal of physiology. Lung cellular and molecular physiology · 2022Article
- BPIFA1 is a secreted biomarker of differentiating human airway epithelium.Frontiers in cellular and infection microbiology · 2022Article
- SPLUNC1: a novel marker of cystic fibrosis exacerbations.The European respiratory journal · 2021Article
- BPIFA1 regulates lung neutrophil recruitment and interferon signaling during acute inflammation.American journal of physiology. Lung cellular and molecular physiology · 2019Article
- Association of innate defense proteins BPIFA1 and BPIFB1 with disease severity in COPD.International journal of chronic obstructive pulmonary disease · 2018Article
- An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection.Mucosal immunology · 2018Article
- [Streptococcus pneumoniae induces SPLUNC1 and the regulatory effects of resveratrol].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Short Palate, Lung, and Nasal Epithelial Clone 1 Has Antimicrobial and Antibiofilm Activities against the Burkholderia cepacia Complex.Antimicrobial agents and chemotherapy · 2016Article
- Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Bactericidal/Permeability-increasing protein fold-containing family member A1 in airway host protection and respiratory disease.American journal of respiratory cell and molecular biology · 2015Review
- EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production.American journal of physiology. Lung cellular and molecular physiology · 2014Article
- Investigation of anti-infection mechanism of lactoferricin and splunc-1.Evidence-based complementary and alternative medicine : eCAM · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Short palate, lung, and nasal epithelial clone-1 (SPLUNC1) is a protein abundantly expressed by the respiratory epithelium of the proximal lower respiratory tract, a site of great environmental exposure. Previous studies showed that SPLUNC1 exerts antimicrobial effects, regulates airway surface liquid and mucociliary clearance, and suppresses allergic airway inflammation. We studied SPLUNC1 to gain insights into its role in host defense. In the lower respiratory tract, concentrations of SPLUNC1 are high under basal conditions. In models of pneumonia caused by common respiratory pathogens, and in Th1-induced and Th2-induced airway inflammation, SPLUNC1 secretion is markedly reduced. Pathogen-associated molecular patterns and IFN-γ act directly on airway epithelial cells to inhibit SPLUNC1 mRNA expression. Thus, SPLUNC1 is quickly suppressed during infection, in response to an insult on the epithelial surface. These experiments highlight the finely tuned fluctuations of SPLUNC1 in response to exposures in the respiratory tract, and suggest that the loss of SPLUNC1 is a crucial feature of host defense across air-breathing animal species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.