Evidence map›Paper›PMID 23470218›Full record

ReviewCritical care (London, England)2013

Stress hyperglycemia: an essential survival response!

Paul E Marik, Rinaldo Bellomo

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 352 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
352citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04150978 nacompletednot on this mapstarted 2017, after this paper: background citation

Effectiveness of Early Enteral Feeding With High Protein Formulas Versus Oligomeric Formula Versus 5% Dextrose Solution in Clinical Improvement and Malnutrition Prevention of Intensive Care Unit Patients. A Quasi-Experimental Design

TypeinterventionalSponsorHasanuddin UniversityRan2017 to 2018Enrolled60ConditionsCritically Ill, Intensive Care UnitArmsHigh Protein Polymeric Formula, Oligomeric Formula, 5% Dextrose
NCT06249113 nacompletednot on this mapstarted 2023, after this paper: background citation

Effectiveness of Adjuvant Continuous Lidocaine in General Anesthesia on Depth of Anesthesia (qCON), Pain Response (qNOX), and Blood Sugar Levels in Elective Primary Tumor Craniotomy Surgery

TypeinterventionalSponsorIndonesia UniversityRan2023 to 2024Enrolled60ConditionsSurgery, Anesthesia, Functional, Haemodynamic InstabilityArmsNaCl 0.9%, Adjuvant lidocaine continous
3 · Its place in the literature

Who cites it

352 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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292 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Paul E Marik
Rinaldo Bellomo

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stress hyperglycemia is common in critically ill patients and appears to be a marker of disease severity. Furthermore, both the admission as well as the mean glucose level during the hospital stay is strongly associated with patient outcomes. Clinicians, researchers and policy makers have assumed this association to be causal with the widespread adoption of protocols and programs for tight in-hospital glycemic control. However, a critical appraisal of the literature has demonstrated that attempts at tight glycemic control in both ICU and non-ICU patients do not improve health care outcomes. We suggest that hyperglycemia and insulin resistance in the setting of acute illness is an evolutionarily preserved adaptive responsive that increases the host's chances of survival. Furthermore, attempts to interfere with this exceedingly complex multi-system adaptive response may be harmful. This paper reviews the pathophysiology of stress hyperglycemia and insulin resistance and the protective role of stress hyperglycemia during acute illness.

Indexed as

AnimalsBlood GlucoseCritical CareCritical IllnessGlycemic IndexHumansHyperglycemiaStress, PhysiologicalSurvivalBlood Glucose

Identifiers

PMID23470218
PMCPMC3672537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.