ArticlePloS one2013
Neuropsychological and socio-occupational functioning in young psychiatric outpatients: a longitudinal investigation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review.BMC psychiatry · 2016Pooled it
- Brief Web-Based Psychological Intervention for Depressive Symptoms Among Chinese Adolescents: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
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- Psychosocial Interventions, Recovery, and Mediating Mechanisms in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis of Longitudinal Studies.Brain sciences · 2026Review
- The Association between Oscillatory Burst Features and Human Working Memory Accuracy.Journal of cognitive neuroscience · 2026Article
- The Tower of London task in children and adolescents with neuropsychiatric disorders.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025Article
- Relationship between cognitive function and functional outcomes in remitted major depression.BMC psychiatry · 2024Article
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- Prevalence of cognitive impairments and strengths in the early course of psychosis and depression.Psychological medicine · 2023Article
- Current Evidence and Theories in Understanding the Relationship between Cognition and Depression in Childhood and Adolescence: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- The Use of Smartphone Serious Gaming Apps in the Treatment of Substance Use Disorders: Observational Study on Feasibility and Acceptability.JMIR formative research · 2022Article
- The relations between executive functions and occupational functioning in individuals with bipolar disorder: a scoping review.International journal of bipolar disorders · 2022Article
- Protocol for a young adult mental health (Uspace) cohort: personalising multidimensional care in young people admitted to hospital.BMJ open · 2021Article
- The MATRICS Consensus Cognitive Battery: Psychometric Properties of the Chinese Version in Young Patients With Major Depression Disorder.Frontiers in psychiatry · 2021Article
- Phase-Amplitude Coupling, Mental Health and Cognition: Implications for Adolescence.Frontiers in human neuroscience · 2021Review
- Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2020Article
- Modelling associations between neurocognition and functional course in young people with emerging mental disorders: a longitudinal cohort study.Translational psychiatry · 2020Article
- Subjective experiences of neurocognitive functioning in young people with major depression.BMC psychiatry · 2019Article
- Caregiver assisted home-based cognitive remediation for individuals diagnosed with schizophrenia: A pilot study.Asian journal of psychiatry · 2019Article
- Attention Deficits in a Comorbidity-Free Sample of Euthymic Pediatric Bipolar Disorder.Frontiers in psychiatry · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical symptoms and neuropsychological deficits are longitudinally associated with functional outcome in chronic psychiatric cohorts. The current study extended these findings to young and early-course psychiatric outpatients, with the aim of identifying cognitive markers that predict later socio-occupational functioning.
methodsAt baseline, 183 young psychiatric outpatients were assessed. Ninety-three returned for follow-up (M = 21.6 years old; SD = 4.5) with an average re-assessment interval of 21.6 months (SD = 7.0), and primary diagnoses of major depressive disorder (n = 34), bipolar disorder (n = 29), or psychosis (n = 30). The primary outcome measure was cross-validated with various other functional measures and structural equation modelling was used to map out the interrelationships between predictors and later functional outcome.
resultsGood socio-occupational functioning at follow-up was associated with better quality of life, less disability, current employment and being in a romantic relationship. The final structural equation model explained 47.5% of the variability in functional outcome at follow-up, with baseline neuropsychological functioning (a composite of memory, working memory and attentional switching) the best independent predictor of later functional outcome. Notably, depressive and negative symptoms were only associated with functioning cross-sectionally. Diagnosis at follow-up was not associated with functional outcome.
conclusionsNeuropsychological functioning was the single best predictor of later socio-occupational outcome among young psychiatric outpatients. Therefore, framing psychiatric disorders along a neuropsychological continuum is likely to be more useful in predicting functional trajectory than traditional symptom-based classification systems. The current findings also have implications for early intervention utilising cognitive remediation approaches.
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