ArticlePloS one2013
The PPE domain of PPE17 is responsible for its surface localization and can be used to express heterologous proteins on the mycobacterial surface.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The PE/PPE family proteins ofFrontiers in immunology · 2025Review
- Novel role of PE_PGRS47 in the alteration of mycobacterial cell wall integrity and drug resistance.Archives of microbiology · 2023Article
- Tailored co-localization analysis of intracellular microbes and punctum-distributed phagosome-lysosome pathway proteins using ImageJ plugin EzColocalization.Scientific reports · 2021Article
- Essential Nucleoid Associated Protein mIHF (Rv1388) Controls Virulence and Housekeeping Genes in Mycobacterium tuberculosis.Scientific reports · 2018Article
- Article
- PPE17 (Rv1168c) protein of Mycobacterium tuberculosis detects individuals with latent TB infection.PloS one · 2018Article
- The Enigmatic PE/PPE Multigene Family of Mycobacteria and Tuberculosis Vaccination.Infection and immunity · 2017Review
- Article
- Article
- Article
- Mycobacterium tuberculosis Resists Stress by Regulating PE19 Expression.Infection and immunity · 2015Article
- PPE57 induces activation of macrophages and drives Th1-type immune responses through TLR2.Journal of molecular medicine (Berlin, Germany) · 2015Article
- PE11 (Rv1169c) selectively alters fatty acid components of Mycobacterium smegmatis and host cell interleukin-6 level accompanied with cell death.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
PPE represent a peculiar family of mycobacterial proteins characterized by a 180 aminoacids conserved N-terminal domain. Several PPE genes are co-transcribed with a gene encoding for a protein belonging to another family of mycobacterial specific proteins named PE. Only one PE-PPE couple has been extensively characterized so far (PE25-PPE41) and it was shown that these two proteins form a heterodimer and that this interaction is essential for PPE41 stability and translocation through the mycobacterial cell wall. In this study we characterize the PE11-PPE17 couple. In contrast with what was found for PE25-PPE41, we show that PPE17 is not secreted but surface exposed. Moreover, we demonstrate that the presence of PE11 is not necessary for PPE17 stability or for its localization on the mycobacterial surface. Finally, we show that the PPE domain of PPE17 targets the mycobacterial cell wall and that this domain can be used as a fusion partner to expose heterologous proteins on the mycobacterial surface.
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