ArticlePloS one2013
Gut microbiota patterns associated with colonization of different Clostridium difficile ribotypes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed.
- High Dose Intramuscular Vitamin D3 Supplementation Impacts the Gut Microbiota of Patients WithFrontiers in cellular and infection microbiology · 2022Trial
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- A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections.BMC infectious diseases · 2015Trial
- Dual Fluorescent Labeling for Bacterial Aggregation Assays.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Review
- A Comparison of Currently Available and Investigational Fecal Microbiota Transplant Products for RecurrentAntibiotics (Basel, Switzerland) · 2024Review
- Fungal and bacterial gut microbiota differ betweenMicrobiome research reports · 2024Article
- Review
- Protective Effect of Baicalin againstAntibiotics (Basel, Switzerland) · 2021Article
- Mucin-Degrading Microbes Release Monosaccharides That ChemoattractACS infectious diseases · 2021Article
- Gut microbiome andTherapeutic advances in gastroenterology · 2021Review
- Characterization of Gut Microbiota in Hospitalized Patients with Clostridioides difficile Infection.Current microbiology · 2020Article
- Intestinal Microbiota in Elderly Inpatients withInfection and drug resistance · 2020Article
- Successional Dynamics in the Gut Microbiome Determine the Success ofFrontiers in cellular and infection microbiology · 2019Article
- Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.Journal of pediatric gastroenterology and nutrition · 2019Article
- Interactions BetweenFrontiers in microbiology · 2018Article
- Evaluating the effect of Clostridium difficile conditioned medium on fecal microbiota community structure.Scientific reports · 2017Article
- Gut microbiota composition and Clostridium difficile infection in hospitalized elderly individuals: a metagenomic study.Scientific reports · 2016Article
- Clostridium difficile infection: epidemiology, diagnosis and understanding transmission.Nature reviews. Gastroenterology & hepatology · 2016Review
- Identification of risk factors influencing Clostridium difficile prevalence in middle-size dairy farms.Veterinary research · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C. difficile infection is associated with disturbed gut microbiota and changes in relative frequencies and abundance of individual bacterial taxons have been described. In this study we have analysed bacterial, fungal and archaeal microbiota by denaturing high pressure liquid chromatography (DHPLC) and with machine learning methods in 208 faecal samples from healthy volunteers and in routine samples with requested C. difficile testing. The latter were further divided according to stool consistency, C. difficile presence or absence and C. difficile ribotype (027 or non-027). Lower microbiota diversity was a common trait of all routine samples and not necessarily connected only to C. difficile colonisation. Differences between the healthy donors and C. difficile positive routine samples were detected in bacterial, fungal and archaeal components. Bifidobacterium longum was the single most important species associated with C. difficile negative samples. However, by machine learning approaches we have identified patterns of microbiota composition predictive for C. difficile colonization. Those patterns also differed between samples with C. difficile ribotype 027 and other C. difficile ribotypes. The results indicate that not only the presence of a single species/group is important but that certain combinations of gut microbes are associated with C. difficile carriage and that some ribotypes (027) might be associated with more disturbed microbiota than the others.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.